Observational studyThe Lancet. Planetary health2024
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study.
Observational study in The Lancet. Planetary health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07124949 (Chinese Migrant Population Health Cohort), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chinese Migrant Population Health Cohort
Who cites it
10 citing papers in PubMed.
- Gestational misalignment with fixed exposure windows: the potential dangers of zero-filling in distributed lag models.International journal of epidemiology · 2026Article
- Gene-Temperature Interactions and Risk of Childhood Acute Lymphoblastic Leukemia.medRxiv : the preprint server for health sciences · 2026Article
- Early-life exposure to ambient temperature and polycystic ovary syndrome: a nationwide cohort study.International journal of epidemiology · 2026Article
- Postoperative Risk and Climate Exposure: A Retrospective Study of Incisional Glaucoma Surgery Outcomes.Translational vision science & technology · 2026Article
- The Mutational Epidemiology of Childhood Cancer.Clinical chemistry · 2025Review
- Traffic-related air pollution exposure at birth and risk of childhood leukemia: results from the GEOCAP-Birth case-control study.Environmental health : a global access science source · 2025Article
- Prevalence rate of perceived gender discrimination and its associations with suicide behaviors in Chinese adolescents: the mediating roles of depressive symptoms and anxiety symptoms.European child & adolescent psychiatry · 2025Article
- Climate change will impact childhood cancer risks, care and outcomes.BMJ paediatrics open · 2025Article
- Investigating the Impact of LNA-anti-miR-92b, miR-181b, TNF-α, and Piperine on Gene Expression and Cell Viability in Jurkat Cells: Implications for Acute Lymphoblastic Leukemia : LNA-anti- MicroRNAs and Jurkat Cells.Galen medical journal · 2025Article
- Prognostic value, biological role, and mechanisms of LCN2 in childhood acute lymphoblastic leukemia.American journal of cancer research · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundHigh ambient temperature is increasingly common due to climate change and is associated with risk of adverse pregnancy outcomes. Acute lymphoblastic leukaemia is the most common malignancy in children, the incidence is increasing, and in the USA disproportionately affects Latino children. We aimed to investigate the potential association between high ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia.
methodsWe used data from California birth records (children born from Jan 1, 1982, to Dec 31, 2015) and California Cancer Registry (those diagnosed with childhood cancer in California from Jan 1, 1988, to Dec 31, 2015) to identify acute lymphoblastic leukaemia cases diagnosed in infants and children aged 14 years and younger and controls matched by sex, race, ethnicity, and date of last menstrual period. Ambient temperatures were estimated on a 1-km grid. The association between ambient temperature and acute lymphoblastic leukaemia was evaluated per gestational week, restricted to May-September, adjusting for confounders. Bayesian meta-regression was applied to identify critical exposure windows. For sensitivity analyses, we evaluated a 90-day pre-pregnancy period (assuming no direct effect before pregnancy), adjusted for relative humidity and particulate matter less than 2·5 microns in aerodynamic diameter, and constructed an alternatively matched dataset for exposure contrast by seasonality.
findings6849 cases of childhood acute lymphoblastic leukaemia were identified and, of these, 6258 had sufficient data for study inclusion. We also included 307 579 matched controls. Most of the study population were male (174 693 [55·7%] of the 313 837 included in the study) and of Latino ethnicity (174 906 [55·7%]). The peak association between ambient temperature and risk of acute lymphoblastic leukaemia was observed in gestational week 8, where a 5°C increase was associated with an odds ratio of 1·07 (95% CI 1·04-1·11). A slightly larger effect was seen among Latino children (OR 1·09 [95% CI 1·04-1·14]) than non-Latino White children (OR 1·05 [1·00-1·11]). The sensitivity analyses supported the results of the main analysis.
interpretationOur findings suggest an association between high ambient temperature in early pregnancy and risk of childhood acute lymphoblastic leukaemia. Further replication and investigation of mechanistic pathways might inform mitigation strategies.
fundingYale Center on Climate Change and Health, The National Center for Advancing Translational Science, National Institutes of Health.
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