Evidence map›Paper›PMID 38969382›Full record

ArticleBMJ open2024

Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study protocol: a prospective observational cohort study of reproductive-aged women living with HIV.

Deborah Kacanek, Lynn M Yee, Tzy-Jyun Yao, Jessica Lee, Ellen G Chadwick, Paige L Williams, Emily A Barr, Claire A Berman, Mariam Davtyan, Alex DiPerna and 20 more

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Deborah KacanekCenter for Biostatistics in AIDS Research, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA dkacanek@sdac.harvard.edu.ORCID 0000-0002-4877-2646
Lynn M YeeDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Tzy-Jyun YaoCenter for Biostatistics in AIDS Research, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-7744-5057
Jessica LeeCenter for Biostatistics in AIDS Research, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Ellen G ChadwickDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Paige L WilliamsDepartments of Epidemiology and Biostatistics, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Emily A BarrThe University of Texas Health Science Center at Houston Cizik School of Nursing, Houston, Texas, USA.
Claire A BermanDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Mariam DavtyanDepartment of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Alex DiPernaFrontier Science Foundation, Amherst, New York, USA.
Amanda FloresDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Jennifer GreenWestat Inc, Rockville, Maryland, USA.
Lisa B HaddadPopulation Council Center for Biomedical Research, New York City, New York, USA.
Laurie HyzyFrontier Science Foundation, Amherst, New York, USA.
Denise L JacobsonCenter for Biostatistics in AIDS Research, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Tamarra James-ToddDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Jennifer JaoDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Anisa KhadraouiDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Kathleen M MaleeDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Anna-Barbara MoscickiUniversity of California Los Angeles, Los Angeles, California, USA.
Kunjal PatelDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Lisa-Gaye RobinsonBroward Health, Children's Diagnostic and Treatment Center, Fort Lauderdale, Florida, USA.
Liz SalomonDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Kimbrae SandersBaylor Texas Children's Hospital, Houston, Texas, USA.
Suzanne SiminskiFrontier Science Foundation, Amherst, New York, USA.
Renee A SmithDepartment of Pediatrics, University of Illinois Chicago, Chicago, Illinois, USA.
Tracy WolbachWestat Inc, Rockville, Maryland, USA.
Kathleen M PowisDepartments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) Study
Health Outcomes in Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) Study

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
The Adolescent Master Protocol (AMP) Up Series ProjectP01HD103133 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHADWICK, ELLEN GOULD, HERNANDEZ-DIAZ, SONIA · 2020 to 2024
$88.3M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
Health Outcomes around Pregnancy and Exposure to HIV/ARV (HOPE): Extending the Reach of PHACS to Examine Women's HealthR01HD101351 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHADWICK, ELLEN GOULD, KACANEK, DEBORAH · 2020 to 2025
$14.6M
NICHD NIH HHS P01 HD103133NICHD NIH HHS R01 HD101351NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104
6 · The paper itself

Abstract

introductionOver 265 000 women are living with HIV in the USA, but limited research has investigated the physical, mental and behavioural health outcomes among women living with HIV of reproductive age. Health status during the reproductive years before, during and after pregnancy affects pregnancy outcomes and long-term health. Understanding health outcomes among women living with HIV of reproductive age is of substantial public health importance, regardless of whether they experience pregnancy. The Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study is a prospective observational cohort study designed to investigate physical and mental health outcomes of young women living with HIV as they age, including HIV disease course, engagement in care, reproductive health and choices and cardiometabolic health. We describe the HOPE study design, and characteristics of the first 437 participants enrolled as of 1 January 2024. METHODS AND ANALYSIS: The HOPE study seeks to enrol and follow 1630 women living with HIV of reproductive age, including those with perinatally-acquired HIV, at 12 clinical sites across 9 US states and Puerto Rico. HOPE studies multilevel dynamic determinants influencing physical, mental and social well-being and behaviours of women living with HIV across the reproductive life course (preconception, pregnancy, post partum, not or never-pregnant), informed by the socioecological model. Key research areas include the clinical course of HIV, relationship of HIV and antiretroviral medications to reproductive health, pregnancy outcomes and comorbidities and the influence of racism and social determinants of health. HOPE began enrolling in April 2022. ETHICS AND DISSEMINATION: The HOPE study received approval from the Harvard Longwood Campus Institutional Review Board, the single institutional review board of record for all HOPE sites. Results will be disseminated through conference presentations, peer-reviewed journals and lay summaries.

Indexed as

HIV InfectionsPregnancy Complications, InfectiousAdolescentAdultAnti-HIV AgentsAnti-Retroviral AgentsFemaleHumansMental HealthObservational Studies as TopicPregnancyPregnancy OutcomeProspective StudiesReproductive HealthResearch DesignUnited StatesAnti-HIV AgentsAnti-Retroviral AgentsHealth EquityHIV & AIDSMENTAL HEALTHObservational StudyPostpartum WomenPregnant Women

Identifiers

PMID38969382
PMCPMC11228391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.