Evidence map›Paper›PMID 38969369›Full record

ArticleBMJ open2024

Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis.

Ali Jafari, Kosar Kordkatuli, Helia Mardani, Fatemeh Mehdipoor, Pardis Bakhtiari Jami, Maryam Abbastabar, Mohammadali Vakili, Sima Besharat, Alireza Alaghi

Abstract read
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali JafariStudent Research Committee, Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran ajafari.nut@gmail.com alirezaalaghi@gmail.com.ORCID 0000-0001-7343-027X
Kosar KordkatuliStudent Research Committee, Department of Public Health, School of Health, Golestan University of Medical Sciences, Gorgan, Iran.
Helia MardaniStudent Research Committee, Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran.
Fatemeh MehdipoorDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Pardis Bakhtiari JamiStudent Research Committee, Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran.
Maryam AbbastabarDepartment of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Mohammadali VakiliHealth Management and Social Development Research Center, Department of Biostatistics and Epidemiology, Golestan University of Medical Sciences, Gorgan, Iran.
Sima BesharatGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Alireza AlaghiSystematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran ajafari.nut@gmail.com alirezaalaghi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHeart diseases constitute a significant global public health concern. Cardiovascular diseases (CVDs) are characterised by disruptions in blood circulation and are notably prevalent among adults exposed to Westernised diets. Ginseng, a medicinal plant, has been recognised for its healing properties and has a history of use spanning thousands of years. This systematic review aims to evaluate the efficacy of ginseng in modifying risk factors for CVD, including lipid profiles, glycaemic control, anthropometric indices, inflammation indicators, blood pressure, oxidative stress, liver function tests, adipokines and heart rate among individuals aged 18 and above, encompassing both genders. METHODS AND ANALYSIS: We will conduct an electronic search for articles published from inception to September 2023 using a predefined search strategy in PubMed, Scopus, Web of Science, CENTRAL and EMBASE. Our search will focus exclusively on randomised controlled clinical trials involving both healthy and unhealthy participants. The process of reviewing articles, extracting pertinent information and assessing the quality of studies using the Cochrane risk of bias tool will be carried out independently by two reviewers. Any discrepancies will be resolved through discussion with a third party. If a sufficient number of eligible studies are identified, a meta-analysis will be conducted using these outcomes. ETHICS AND DISSEMINATION: This study serves as the procedural framework for a comprehensive examination and does not require ethical approval. Additionally, the study adhered to the guidelines outlined in the Declaration of Helsinki. Ethical approval for the study was obtained from the Ethics Committee of Golestan University of Medical Sciences (IR.GOUMS.REC.1402.298). PROSPERO REGISTRATION NUMBER: CRD42023465688.

Indexed as

Cardiovascular DiseasesDietary SupplementsMeta-Analysis as TopicPanaxSystematic Reviews as TopicDose-Response Relationship, DrugHeart Disease Risk FactorsHumansPlant ExtractsResearch DesignPlant Extractscardiovascular diseasemeta-analysisnutrition

Identifiers

PMID38969369
PMCPMC11227762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.