Evidence map›Paper›PMID 38968642›Full record

ArticleAtherosclerosis2024

Peripheral artery disease, chronic kidney disease, and recurrent admissions for acute decompensated heart failure: The ARIC study.

Zainali S Chunawala, Deepak L Bhatt, Arman Qamar, Muthiah Vaduganathan, Robert J Mentz, Kunihiro Matsushita, Justin L Grodin, Ambarish Pandey, Melissa C Caughey

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zainali S ChunawalaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Deepak L BhattMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Arman QamarSection of Interventional Cardiology, Division of Cardiology, NorthShore University Healthsystem, Evanston, IL, USA.
Muthiah VaduganathanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Robert J MentzDivision of Cardiology, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC, USA.
Kunihiro MatsushitaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Justin L GrodinDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ambarish PandeyDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Melissa C CaugheyJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, USA. Electronic address: caughey@med.unc.edu.

Funding

IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELER01HL160892 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Justin Lee Grodin · 2022 to 2026
$3.6M
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL160892
6 · The paper itself

Abstract

BACKGROUND AND

aimsPeripheral artery disease (PAD) has not only been associated with recurrent hospitalization for acute decompensated heart failure (ADHF) but is also associated with chronic kidney disease (CKD), a known risk factor for worse heart failure outcomes. The interaction of CKD with PAD in post-discharge ADHF outcomes is not well known.

methodsSince 2005, hospitalizations for ADHF were sampled from 4 US regions by the Atherosclerosis Risk in Communities (ARIC) study and classified by physician review. We examined the adjusted association of PAD with 1-year ADHF readmissions, in patients with and without CKD (defined by glomerular filtration rate [GFR] ≤60 mL/min/1.73 m

resultsFrom 2005 to 2018, there were 1049 index hospitalizations for patients with ADHF (mean age 77 years, 66 % white) with creatinine data, who were discharged alive. Of these, 155 (15 %) had PAD and 66 % had CKD. In comparison to those without PAD, patients with PAD had more comorbid conditions and higher 1-year ADHF readmission rates, irrespective of CKD status. After adjustment, PAD was associated with a greater risk of 1-year ADHF readmissions, both for patients with concomitant CKD (HR, 1.70; 95 % CI: 1.29-2.24) and those without CKD (HR, 1.97; 95 % CI: 1.14-3.40); p-interaction = 0.8.

conclusionAmong patients hospitalized with ADHF, those with concurrent PAD have more prevalent cardiovascular comorbidities and higher likelihood of 1-year ADHF readmission, irrespective of CKD status. Integrating a more holistic approach in management of patients with concomitant heart failure, PAD and CKD may be an important strategy to improve the prognosis in this vulnerable population.

Indexed as

Heart FailurePatient ReadmissionPeripheral Arterial DiseaseRenal Insufficiency, ChronicAcute DiseaseAgedAged, 80 and overComorbidityFemaleGlomerular Filtration RateHospitalizationHumansMaleMiddle AgedRecurrenceRisk AssessmentChronic kidney diseaseEpidemiologyHeart failureHospitalizationPeripheral artery diseaseSurveillance

Identifiers

PMID38968642
PMCPMC11382611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.