Evidence map›Paper›PMID 38968411›Full record

ArticleDiabetes care2024

Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study.

Justine Cole, Claire Guivarch, Jing Wu, Paulina Stallcup, Wei Wei Pang, Cuilin Zhang, David B Sacks

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justine ColeDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-0278-4094
Claire GuivarchGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-5415-6954
Jing WuGlotech Inc., Bethesda, MD.
Paulina StallcupDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
Wei Wei PangGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-5938-7022
Cuilin ZhangGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-8014-2708
David B SacksDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-3100-0735

Funding

CLC NIH HHS Intramural research programNICHD NIH HHS HHSN275200800002CNICHD NIH HHS HHSN275200800002INICHD NIH HHS HHSN275200800003CNICHD NIH HHS HHSN275200800003INICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275201000009CNIH HHS HHSN275200800013C, HHSN275200800002I, HHSN27500006
6 · The paper itself

Abstract

objectiveTo investigate associations of plasma glycated albumin (GA) concentrations in early and midpregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND

methodsWe measured GA concentrations using blood samples collected at 10-14 and 15-26 weeks' gestation in 107 GDM case and 214 control participants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. We performed generalized linear mixed-effect regression to test the mean GA difference between GDM case and control participants and conditional logistic regression to assess prospective associations between GA concentrations and GDM risk.

resultsAt 15-26 weeks' gestation mean GA was lower in GDM case participants than in control participants (mean 11.90% [95% CI 6.42-32.76] vs. 12.46% [8.45-38.35], adjusted P value for difference = 0.004). Consistently, women with higher GA concentrations tended to have a lower GDM risk, although the associations were not statistically significant.

conclusionsThis study suggests that GA concentrations in midpregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.

Indexed as

Diabetes, GestationalGlycated Serum AlbuminGlycation End Products, AdvancedSerum AlbuminAdultFemaleHumansLongitudinal StudiesPregnancyProspective StudiesGlycated Serum AlbuminGlycation End Products, AdvancedSerum Albumin

Identifiers

PMID38968411
PMCPMC11362106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.