Evidence map›Paper›PMID 38968266›Full record

ArticlePloS one2024

The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study.

Tainá Veras de Sandes-Freitas, Lucio Requião Moura, Deise Rosa de Boni Monteiro de Carvalho, Valter Duro Garcia, Luis Gustavo Modelli de Andrade, Marilda Mazzali, Roberto Ceratti Manfro, Luciane Mônica Deboni, Elias Davi-Neto, Claudia Maria Costa de Oliveira and 12 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Tainá Veras de Sandes-FreitasDepartamento de Medicina Clínica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-4435-0614
Lucio Requião MouraHospital do Rim, Fundação Oswaldo Ramos, São Paulo, São Paulo, Brazil.
Deise Rosa de Boni Monteiro de CarvalhoCentro Avançado de Transplante de Órgãos e Tecidos, Hospital São Francisco na Providência de Deus, Rio de Janeiro, Rio de Janeiro, Brazil.
Valter Duro GarciaCentro de Transplantes, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Luis Gustavo Modelli de AndradeDepartamento de Medicina Interna, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
Marilda MazzaliDisciplina de Nefrologia, Faculdade de Ciencias Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
Roberto Ceratti ManfroServiço de Nefrologia, Unidade de Transplante Renal, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Luciane Mônica DeboniServiço de Transplante, Hospital Municipal São José de Joinville, Fundação Pró-Rim, Joinville, Santa Catarina, Brazil.
Elias Davi-NetoServiço de Transplante renal, Hospital de Clínicas da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Claudia Maria Costa de OliveiraServiço de Nefrologia e Transplante Renal, Hospital Universitário Walter Cantídio, Fortaleza, Ceará, Brazil.
Frederico Castelo Branco CavalcantiUnidade de Nefrologia, Real Hospital Português de Beneficência em Pernambuco, Recife, Pernambuco, Brazil.
Rafael Lage MadeiraUnidade de Transplante Renal, Hospital Felício Rocho, Belo Horizonte, Minas Gerais, Brazil.
Ronaldo de Matos EsmeraldoSetor de Transplantes, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil.
Denise Rodrigues SimãoDepartamento de Transplante Renal, Hospital Santa Isabel, Blumenau, Santa Catarina, Brazil.
Ana Carolina Guedes MeiraUnidade de Transplante Renal, Santa Casa Montes Claros, Montes Claros, Minas Gerais, Brazil.
Gustavo Fernandes FerreiraUnidade de Transplante Renal, Santa Casa de Misericórdia de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-0036-0298
Marcus LasmarServiço de Nefrologia, Hospital Universitário Ciências Médicas, Belo Horizonte, Minas Gerais, Brazil.
Alexandre Tortoza BignelliUnidade de Transplante Renal, Hospital Universitário Cajuru, Curitiba, Paraná, Brazil.
Alvaro Pacheco-SilvaHospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.
José Medina PestanaHospital do Rim, Fundação Oswaldo Ramos, São Paulo, São Paulo, Brazil.
Hélio Tedesco SilvaHospital do Rim, Fundação Oswaldo Ramos, São Paulo, São Paulo, Brazil.
DGF-Brazil Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.

Indexed as

Delayed Graft FunctionKidney TransplantationOrgan PreservationOrgan Preservation SolutionsAdultBrazilFemaleGraft SurvivalHumansMaleMiddle AgedRetrospective StudiesOrgan Preservation Solutions

Identifiers

PMID38968266
PMCPMC11226083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.