Evidence map›Paper›PMID 38968112›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.

Swati Gupta, Alexander Tielemans, Christopher A Guevara, George W Huntley, Deanna L Benson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Swati GuptaNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Alexander TielemansNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0001-5671-2144
Christopher A GuevaraNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0001-6755-9317
George W HuntleyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0003-3645-6192
Deanna L BensonNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0001-7037-1147

Funding

Training Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0M
Investigating the Neurobiology of Early Cognitive ImpairmentR01NS135728 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson, GEORGE W. HUNTLEY · 2024 to 2026
$2.3M
Impact of human disease-causing mutation on striatal synaptic and behavioral plasticityR01NS107512 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2019 to 2022
$2.1M
Leica TCS SP8 STED3XS10OD021838 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L · 2017 to 2017
$1.2M
A Model for Homeostatic Plasticity in StriatumR21NS130841 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2023 to 2023
$465k
HHS | NIH | National Institute of Mental Health (NIMH) T32-MH087004HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS107512HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS135728HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NS130841HHS | NIH | Office of Research Infrastructure Programs (ORIP) S10OD021838Michael J. Fox Foundation for Parkinson's Research (MJFF) MJFF 022867NIH HHS S10 OD021838NIMH NIH HHS T32 MH087004NINDS NIH HHS R01 NS107512NINDS NIH HHS R01 NS135728NINDS NIH HHS R21 NS130841Rainwater Charitable Foundation (RCF) tau leadership fellow
6 · The paper itself

Abstract

Parkinson's disease (PD) is a multifactorial disease that affects multiple brain systems and circuits. While defined by motor symptoms caused by degeneration of brainstem dopamine neurons, debilitating non-motor abnormalities in fronto-striatal-based cognitive function are common, appear early, and are initially independent of dopamine. Young adult mice expressing the PD-associated G2019S missense mutation in

Indexed as

Corpus StriatumLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseProtein TransportReceptors, AMPAAnimalsHumansMiceMutation, MissenseReceptors, GlutamateSynapsesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk2 protein, mouseReceptors, AMPAReceptors, Glutamatedirect-pathway SPNendocytosisGluA1LTPreceptor mobility

Identifiers

PMID38968112
PMCPMC11252801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.