ArticleEnvironmental health perspectives2024
Combined Exposures and Mixtures Research: An Enduring NIEHS Priority.
Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.Journal of exposure science & environmental epidemiology · 2025Pooled it
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Article
- Advanced Bayesian kernel machine regression for large-scale exposome studies: Making the impossible possible.Innovation (Cambridge (Mass.)) · 2026Article
- An Epidemiologic Review of Endocrine-disrupting Chemicals and Understudied Gynecologic Health Conditions Affecting Quality of Life.Current environmental health reports · 2026Review
- Predicting toxicity and bioactivity of the chemical exposome: a case study for the blood exposome database.Journal of cheminformatics · 2026Article
- Characterizing Prenatal Exposure to Contemporary and Emerging Chemicals in a Prospective Cohort of Pregnant Women in Atlanta, Georgia.Environment & health (Washington, D.C.) · 2026Article
- Weighted network analysis of adverse outcome pathways decodes the multiscale mechanisms of environmental toxicity.Environmental science and ecotechnology · 2026Article
- Health disparities and industrial emissions: a case study of semiconductor manufacturing and asthma morbidity in Austin, Texas.Population and environment · 2026Article
- Combined prenatal exposure to airborne polycyclic aromatic hydrocarbons and maternal distress is associated with childhood irritability.Frontiers in public health · 2026Article
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- Predicting Toxicity and Bioactivity of the Chemical Exposome: A Case Study for the Blood Exposome Database.bioRxiv : the preprint server for biology · 2025Article
- Exposure mixtures and the near future of improving our understanding of worker health.Occupational and environmental medicine · 2025Article
- Combined Effects of Arsenic, Cadmium, and Mercury with Cardiovascular Disease Risk: Insights from the All of Us Research Program.International journal of environmental research and public health · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundThe National Institute of Environmental Health Sciences (NIEHS) continues to prioritize research to better understand the health effects resulting from exposure to mixtures of chemical and nonchemical stressors. Mixtures research activities over the last decade were informed by expert input during the development and deliberations of the 2011 NIEHS Workshop "Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health Effects." NIEHS mixtures research efforts since then have focused on key themes including
objectivesWe aimed to describe NIEHS driven research on mixtures and combined exposures over the last decade and present areas for future attention.
resultsIntramural and extramural mixtures research projects have incorporated a diverse array of chemicals (e.g., polycyclic aromatic hydrocarbons, botanicals, personal care products, wildfire emissions) and nonchemical stressors (e.g., socioeconomic factors, social adversity) and have focused on many diseases (e.g., breast cancer, atherosclerosis, immune disruption). We have made significant progress in certain areas, such as developing statistical methods for evaluating multiple chemical associations in epidemiology and building translational mixtures projects that include both DISCUSSION: Moving forward, additional work is needed to improve mixtures data integration, elucidate interactions between chemical and nonchemical stressors, and resolve the geospatial and temporal nature of mixture exposures. Continued mixtures research will be critical to informing cumulative impact assessments and addressing complex challenges, such as environmental justice and climate change. https://doi.org/10.1289/EHP14340.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.