Evidence map›Paper›PMID 38967874›Full record

ArticleJapanese journal of ophthalmology2024

Assessment of objective visual function following idebenone administration in patients with leber hereditary optic neuropathy.

Yoichiro Masuda, Hiroto Ishikawa, Hitoshi Ishikawa, Takeshi Kezuka, Atsushi Miyazaki, Kenji Matsumoto, Fumi Gomi, Osamu Mimura, Keigo Shikishima, Tadashi Nakano and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Japanese journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yoichiro MasudaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi Minato-ku, Tokyo, 105-8461, Japan. ymasuda@jikei.ac.jp.
Hiroto IshikawaDepartment of Ophthalmology, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Hitoshi IshikawaDepartment of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Takeshi KezukaDepartment of Ophthalmology, Tokyo Medical University, Nishi‑Shinjuku, Shinjuku‑ku, Tokyo, Japan.
Atsushi MiyazakiBrain Science Institute, Tamagawa University, Tokyo, Japan.
Kenji MatsumotoBrain Science Institute, Tamagawa University, Tokyo, Japan.
Fumi GomiDepartment of Ophthalmology, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Osamu MimuraDepartment of Ophthalmology, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Keigo ShikishimaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi Minato-ku, Tokyo, 105-8461, Japan.
Tadashi NakanoDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi Minato-ku, Tokyo, 105-8461, Japan.
Masahiko TeraoResearch Institute for Time Studies, Yamaguchi University, Yamaguchi, Japan.

Funding

Grant-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science, and Technology of Japan 19K09982Grant-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science, and Technology of Japan 22K09841
6 · The paper itself

Abstract

purposeTo objectively assess visual function in Leber's Hereditary Optic Neuropathy (LHON) patients; this study evaluated pre- and post-idebenone treatment changes in primary visual cortical (V1) responses using functional magnetic resonance imaging (fMRI), given the challenges in subjective testing due to central retinal ganglion cell damage. STUDY

designA descriptive study involving four confirmed LHON patients.

methodsFour patients received 900 mg/day of oral idebenone for 24 weeks. Baseline and post-treatment visual acuity, visual fields, and BOLD fMRI responses while passively viewed drifting contrast pattern visual stimuli were compared with self-reported symptoms.

resultsPost-idebenone, one patient showed positive trends across subjective tests, reported symptoms, and fMRI. Two patients had stable symptoms and fMRI responses; one improved on subjective tests, and another worsened slightly. Another patient improved in visual field tests despite worsening symptoms and fMRI trends.

conclusionfMRI may offer a valuable objective measure of visual functions in LHON and appears to be more relevant in assessing symptoms. Further research with more participants is needed to ascertain fMRI's role in developing objective visual assessments and treatment evaluation.

Indexed as

AntioxidantsMagnetic Resonance ImagingOptic Atrophy, Hereditary, LeberUbiquinoneVisual AcuityVisual FieldsAdministration, OralAdultFemaleHumansMaleMiddle AgedVisual CortexYoung AdultAntioxidantsidebenoneUbiquinoneFunctional MRIIdebenoneLeber’s hereditary optic neuropathyObjective visual functionPrimary visual cortex

Identifiers

PMID38967874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.