SynthesisClinical oral investigations2024
Which are the clinical consequences of Molar Incisor hypomineralization (MIH) in children and adolescents? Systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of treatment of molar-incisor hypomineralisation on children's oral health-related quality of life: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Diode and er: YAG laser therapy versus other desensitizing treatments for dentin hypersensitivity in molar-incisor hypomineralization: a systematic review.Lasers in medical science · 2026Pooled it
- Oral microbiome signatures of molar-incisor hypomineralisation: insights from a pilot study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Oral Health-Related Quality of Life in Pediatric Subjects with Molar Incisor Hypomineralization: An Umbrella Review of Domain-Specific Impact and Treatment-Related Changes.Children (Basel, Switzerland) · 2026Review
- Association between molar-incisor hypomineralisation and occlusal alterations in children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Comparative evaluation of remineralization agents in severe enamel hypomineralization using a porcine enamel model.BMC oral health · 2026Article
- High prevalence of molar-incisor hypomineralisation in sickle cell disease children and the association with haematologic profile: a retrospective cohort study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Prenatal and birth-related risk factors for hypomineralised second primary molars: a prospective cohort study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Prevalence, clinical characteristics, and treatment needs of Molar Incisor Hypomineralization (MIH) in Turkish children: a cross-sectional study.BMC public health · 2026Article
- Severity and extent of hypomineralised defects located on working and balancing cusps: a comparative study between primary and permanent teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- The association of caries prevalence and experience in relation with molar incisor hypomineralisation and its associated factors in Mexican schoolchildren: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Clinical significance of residual yellow-brown enamel opacities in severe molar incisor hypomineralisation: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Article
- Key concepts for clinical management of Molar Incisor Hypomineralization.Brazilian oral research · 2026Review
- Prevalence of molar incisor hypomineralisation and associated factors amongst 8-year-olds in Ireland.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Prevalence of dental caries and its association with molar incisor hypomineralization among 7-10-year-old children in Jeddah, Saudi Arabia. An epidemiological study.The Saudi dental journal · 2025Article
- Developmental Defect of Enamel in Permanent Teeth Associated With Chronic Endodontic Abscess in Deciduous Teeth: A Retrospective Study.Clinical and experimental dental research · 2025Article
- MIH and Cavities as Markers of Oral Health Inequality in Children from Southwest Andalusia (Spain).Dentistry journal · 2025Article
- Prevalence of molar incisor hypomineralization and characteristics of affected first permanent and second primary molars among children in Jeddah.Clinical oral investigations · 2025Article
- To Treat or to Extract Necrotic First Permanent Molars Between 8 and 12 Years of Age: A Retrospective Cohort Study.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review was conducted to address the following research question: "What are the clinical consequences (outcome) of Molar Incisor Hypomineralization (MIH) (exposure) in children and adolescents (population/patient)?". MATERIAL AND
methodsAfter defining the strategy, a search was performed in different databases (MEDLINE via Pubmed, Cochrane Library, BBO, LILACS, Scopus, Web of Science, Embase) and Grey literature in August 2023. Cross-sectional observational studies that identified clinical consequences of MIH (dental caries, post-eruptive structural loss, atypical restorations, hypersensitivity and tooth extraction) were included. The risk of bias was assessed following the Joanna Briggs Institute protocol for cross-sectional studies. Meta-analyses were conducted for each outcome, taking into account the number of patients and teeth. The effect measure considered was the prevalence; random-effects model was adopted. Heterogeneity was assessed using I
resultsA total of 903 studies were identified; 41 were selected for qualitative analysis and 38 for quantitative analysis. Twenty eight studies were classified as presenting uncertain risk of bias, 11 as low risk and 3 as high risk of bias. The prevalence levels, ranked from highest to lowest and considering the tooth and patient units, respectively, were: caries lesions (0.252 - 95% CI 0.158-0.375; 0.512 - 95% CI 0.385-0.639); hypersensitivity (0.286 - 95% CI 0.190-0.407; 0.417 - 95% CI 0.197-0.674), post-eruptive fracture (0.125 - 95% CI 0.099-0.158; 0.257 - 95% CI 0.145-0.412); atypical restorations (0.048 - 95% CI 0.030-0.077; 0.167 - 95% CI 0.096 - 0.274); tooth extraction (0.012 - 95% CI 0.007-0.019; 0.090 - 95% CI 0.019 - 0.331). All meta-analyses resulted in heterogeneity greater than 85%, with the exception of the outcome "tooth extraction" according to the tooth unit (I
conclusionThe most common consequences of MIH are caries lesions, hypersensitivity, and post-eruptive breakdown. (PROSPERO:CRD42020201410).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.