Evidence map›Paper›PMID 38967746›Full record

ReviewAdvances in experimental medicine and biology2024

Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future.

Ming Chu, Ning Fu, Liang Zhang, Meng Yu, Youhui Zhang, Xiaoyan Qiu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ming ChuDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China. famous@bjmu.edu.cn.
Ning FuDepartment of Immunology, Southern Medical University, Guangzhou, China.
Liang ZhangDepartment of BIomedical Sciences, City University of Hong Kong, Hong Kong, SAR, China.
Meng YuShanghai R&D Department, Shanghai Baiying Biotechnology Co., Ltd., Shanghai, China.
Youhui ZhangDepartment of Immunology, Cancer Institute, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Xiaoyan QiuDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The canonical theory of immunology stating that "Immunoglobulin (Ig) is produced by B lymphocytes and exerts antibody activity" has been established since the 1970s. However, the discovery of non B cell-derived Igs (non B-Igs), which can exert multiple biological activities in addition to their antibody activities, necessitates a reevaluation of the classic concept of Ig. This has been documented with a number of characteristics related to their structure, modification, genetic regulation as well as the functions associated with clinical conditions, particularly multiple cancers. The discovery of non B-Ig provides us with a new perspective to better understand not only basic immunology, but also various Ig-related clinical manifestations including autoimmune diseases, chronic inflammation, and anaphylaxis. Notably, non B-Ig can directly promote the occurrence of malignant tumours.

Indexed as

ImmunoglobulinsAnimalsAutoimmune DiseasesB-LymphocytesHumansInflammationNeoplasmsImmunoglobulinsNon B cell-derived immunoglobulins (non B-Igs)

Identifiers

PMID38967746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.