ReviewInternational journal of implant dentistry2024
Beyond microroughness: novel approaches to navigate osteoblast activity on implant surfaces.
Review in International journal of implant dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The surface-agnostic advantage for peri-implant health: UV photofunctionalization as a positive-sum strategy for biofilm suppression and soft-tissue barrier-a systematic review with qualitative synthesis.International journal of implant dentistry · 2026Pooled it
- Bridging the missing middle in osseointegration: meso-scale topography between macro design and microroughness.International journal of implant dentistry · 2025Pooled it
- Specific gene expression patterns associated as reliable biomarkers for predicting dental implant successful osseointegration: a literature review and focused meta-analysis.Frontiers in physiology · 2025Pooled it
- Regulation of Pre-Osteoblasts Seeded onto Titanium and Zirconia Through Modification by Hydrofluoric Acid and LPS Challenge.Dentistry journal · 2026Article
- Effects of UV Photo-Functionalization of Titanium Dental Implants on Osteoblast Responses In Vitro.Biomimetics (Basel, Switzerland) · 2026Article
- Meso-Scale Modifications in Additively Manufactured Zirconia: Topographical Design and Its Influence on Cell-Material Interactions.Bioengineering (Basel, Switzerland) · 2026Article
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Development of a Cerium-Doped Titanate/Polyphenol Nanostructured Coating for Titanium Implants: Enhancing Antibacterial Properties through Ciprofloxacin Release.ACS applied materials & interfaces · 2026Article
- In vitro evaluation of biocompatibility of Ti-20Zr-3Mo-3Sn β-alloy for oral implantology.Scientific reports · 2025Article
- Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics.Materials today. Bio · 2025Review
- The next frontier in osseointegration: energy and speed as critical determinants and their enhancement by UV photofunctionalization.International journal of implant dentistry · 2025Article
- The 3D theory of osseointegration: material, topography, and time as interdependent determinants of bone-implant integration.International journal of implant dentistry · 2025Review
- The Effect of Various Implant Coatings on Bone Formation and Cell Adhesion.Journal of pharmacy & bioallied sciences · 2025Article
- Zinc-Doped Antibacterial Coating as a Single Approach to Unlock Multifunctional and Highly Resistant Titanium Implant Surfaces.ACS applied materials & interfaces · 2025Article
- Nanorough Surface of Fibronectin Grafted Bioactive Zirconia Dental Implants by Using Glow Discharge Plasma Promotes Osseointegration in a Rabbit Model.International journal of nanomedicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considering the biological activity of osteoblasts is crucial when devising new approaches to enhance the osseointegration of implant surfaces, as their behavior profoundly influences clinical outcomes. An established inverse correlation exists between osteoblast proliferation and their functional differentiation, which constrains the rapid generation of a significant amount of bone. Examining the surface morphology of implants reveals that roughened titanium surfaces facilitate rapid but thin bone formation, whereas smooth, machined surfaces promote greater volumes of bone formation albeit at a slower pace. Consequently, osteoblasts differentiate faster on roughened surfaces but at the expense of proliferation speed. Moreover, the attachment and initial spreading behavior of osteoblasts are notably compromised on microrough surfaces. This review delves into our current understanding and recent advances in nanonodular texturing, meso-scale texturing, and UV photofunctionalization as potential strategies to address the "biological dilemma" of osteoblast kinetics, aiming to improve the quality and quantity of osseointegration. We discuss how these topographical and physicochemical strategies effectively mitigate and even overcome the dichotomy of osteoblast behavior and the biological challenges posed by microrough surfaces. Indeed, surfaces modified with these strategies exhibit enhanced recruitment, attachment, spread, and proliferation of osteoblasts compared to smooth surfaces, while maintaining or amplifying the inherent advantage of cell differentiation. These technology platforms suggest promising avenues for the development of future implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.