Evidence map›Paper›PMID 38967675›Full record

ArticleEuropean journal of nutrition2024

Low thiamine status in adults following low-carbohydrate / ketogenic diets: a cross-sectional comparative study of micronutrient intake and status.

Chaitong Churuangsuk, Anthony Catchpole, Dinesh Talwar, Paul Welsh, Naveed Sattar, Michael E J Lean, Emilie Combet

Abstract readComparative Study
In one paragraph

Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chaitong ChuruangsukHuman Nutrition, School of Medicine, Dentistry, and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Room 2.22, Level 2, New Lister Building 10-16 Alexandra Parade, Glasgow, G31 2ER, UK.ORCID http://orcid.org/0000-0003-4373-6395
Anthony CatchpoleScottish Trace Element and Micronutrient Diagnostic and Research Laboratory, Glasgow Royal Infirmary, Glasgow, UK.ORCID http://orcid.org/0000-0001-7744-0029
Dinesh TalwarScottish Trace Element and Micronutrient Diagnostic and Research Laboratory, Glasgow Royal Infirmary, Glasgow, UK.ORCID http://orcid.org/0000-0003-4133-4632
Paul WelshSchool of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-7970-3643
Naveed SattarSchool of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-1604-2593
Michael E J LeanHuman Nutrition, School of Medicine, Dentistry, and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Room 2.22, Level 2, New Lister Building 10-16 Alexandra Parade, Glasgow, G31 2ER, UK.ORCID http://orcid.org/0000-0003-2216-0083
Emilie CombetHuman Nutrition, School of Medicine, Dentistry, and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Room 2.22, Level 2, New Lister Building 10-16 Alexandra Parade, Glasgow, G31 2ER, UK. Emilie.CombetAspray@glasgow.ac.uk.ORCID http://orcid.org/0000-0002-9302-8971

Funding

Faculty of Medicine, Prince of Songkla University PhD studenthsip
6 · The paper itself

Abstract

backgroundLow-carbohydrate diets (LCD) are popular for weight loss but lack evidence about micronutrient sufficiency in real-life use. This study assessed the intake and biochemical status of selected micronutrients in people voluntarily following LCDs.

methodsA cross-sectional study was conducted (2018-20) among 98 adults recruited as self-reporting either LCD (n = 49) or diets not restricting carbohydrates (controls; n = 49). Diets were assessed using the 130-item EPIC-Norfolk food-frequency questionnaire. Red-blood-cell thiamine diphosphate (TDP) was measured for thiamine status using HPLC. Plasma magnesium, zinc, copper, and selenium were measured using inductively coupled plasma mass spectrometry. Between-group biomarker comparisons were conducted using ANCOVA and adjusted for age, sex, body mass index (BMI), and diabetes status.

resultsLCD-followers (26% male, median age 36 years, median BMI 24.2 kg/m

conclusionsFollowing LCDs is associated with lower thiamine intake and TDP status than diets without carbohydrate restriction, incompletely corrected by supplement use. These data, coupled with a lack of RCT evidence on body weight control, do not support recommending LCDs for weight management without appropriate guidance and diet supplementation.

Indexed as

Diet, Carbohydrate-RestrictedDiet, KetogenicMicronutrientsNutritional StatusThiamineAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedThiamine DeficiencyMicronutrientsThiamineKetogenic dietLow carbohydrateMagnesiumMicronutrientObesityThiamine

Identifiers

PMID38967675
PMCPMC11490449

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.