Evidence map›Paper›PMID 38967583›Full record

ArticleInternational forum of allergy & rhinology2024

Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis.

Ethan J Han, Christine M Liu, Jakob L Fischer, Jess C Mace, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Patricia H Eshaghian, Yuqing A Gao and 21 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04469439 (The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04469439 recruitingnot on this map

The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy

TypeobservationalSponsorUniversity of California, Los AngelesRan2020 to 2027Enrolled170ConditionsChronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Health Disparities in Rhinology-A Scoping Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Ethan J HanDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.ORCID 0000-0002-0981-4858
Christine M LiuDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.ORCID 0000-0001-9985-4775
Jakob L FischerDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.
Jess C MaceDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, Oregon, USA.ORCID 0000-0001-5009-3426
Karolin MarkarianCTSI, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0009-0002-0076-3166
Jeremiah A AltDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0560-5028
Todd E BodnerDepartment of Psychology, Portland State University, Portland, Oregon, USA.
Naweed I ChowdhuryDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Patricia H EshaghianDepartment of Pulmonary Medicine, University of California, Los Angeles, California, USA.
Yuqing A GaoDepartment of Pulmonary Medicine, University of California, Los Angeles, California, USA.
Anne E GetzDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Denver, Colorado, USA.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.ORCID 0000-0002-0786-4675
Ashoke KhanwalkarDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Denver, Colorado, USA.ORCID 0000-0001-9960-7758
Adam J KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Jivianne T LeeDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.
Douglas A LiDepartment of Pulmonary Medicine, University of California, Los Angeles, California, USA.
Meghan NorrisDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.ORCID 0000-0003-4454-0861
Cameran OwensDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Zara M PatelDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.ORCID 0000-0003-2072-982X
Katie PochDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Kristine A SmithDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Timothy L SmithDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, Oregon, USA.ORCID 0000-0002-6424-7083
Zachary M SolerDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Jeffrey D SuhDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.
Grant A TurnerDepartment of Pulmonary Medicine, University of California, Los Angeles, California, USA.
Marilene B WangDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.
Jennifer L Taylor-CousarDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Milene T SaavedraDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Daniel M BeswickDepartment of Head and Neck Surgery, University of California, Los Angeles, California, USA.ORCID 0000-0001-8612-5442

Funding

Enabling careers as surgeon-scientists in otolaryngology-head and neck surgeryR25DC020151 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer L Long · 2022 to 2026
$887k
Cystic Fibrosis Foundation BESWIC20A0Cystic Fibrosis Foundation BESWIC22Y5National Institute on Deafness and Other Communication Disorders of the National Institutes of Health R25DC020151NIDCD NIH HHS R25 DC020151
6 · The paper itself

Abstract

backgroundSociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.

methodsIn a prospective, multi-institutional study, adult PwCF completed the 22-Question SinoNasal Outcome Test (SNOT-22), Smell Identification Test (SIT), Questionnaire of Olfactory Disorder Negative Statements (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R). Lund-Kennedy scores, sinus computed tomography, and clinical data were collected. Data were analyzed across race/ethnicity, sex, and socioeconomic factors using multivariate regression.

resultsSeventy-three PwCF participated with a mean age of 34.7 ± 10.9 years and 49 (67.1%) were female. Linear regression identified that elexacaftor/tezacaftor/ivacaftor (ETI) use (β = ‒4.09, 95% confidence interval [CI] [‒6.08, ‒2.11], p < 0.001), female sex (β = ‒2.14, 95% CI [‒4.11, ‒0.17], p = 0.034), and increasing age (β = ‒0.14, 95% CI [‒0.22, ‒0.05], p = 0.003) were associated with lower/better endoscopy scores. Private health insurance (β = 17.76, 95% CI [5.20, 30.32], p = 0.006) and >16 educational years (β = 13.50, 95% CI [2.21, 24.80], p = 0.020) were associated with higher baseline percent predicted forced expiratory volume in one second (ppFEV

conclusionsDifferences in objective measures of CRS severity exist among PwCF related to sex, age, and ETI use. Variant status and race did not influence patient-reported CRS severity measures or olfaction in this study. Understanding how these factors impact response to treatment may improve care disparities among PwCF. CLINICAL TRIALS: NCT04469439.

Indexed as

Cystic FibrosisRhinitisSinusitisAdultChronic DiseaseFemaleHumansMaleMiddle AgedOlfaction DisordersProspective StudiesRhinosinusitisSex FactorsSmellSocial ClassSurveys and Questionnaireschronic rhinosinusitiscystic fibrosispatient symptomssocioeconomic status

Identifiers

PMID38967583
PMCPMC11530317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.