ArticleObesity (Silver Spring, Md.)2024
The subcutaneous adipose transcriptome identifies a molecular signature of insulin resistance shared with visceral adipose.
Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS.JCI insight · 2026Article
- Caspase-6 Controls Lipid and Energy Metabolism in Diet-Induced Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- T-Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues.Obesity (Silver Spring, Md.) · 2026Article
- Association of triglyceride glucose index and volumetric bone mineral density in T2DM: fat distribution as a potential indirect link.Frontiers in cell and developmental biology · 2026Article
- Metabolomics of abdominal adipose tissue samples collected from patients with obesity - a critical review.Molecular and cellular biochemistry · 2026Review
- Adipose tissue aging as a risk factor for metabolic organ abnormalities: mechanistic insights and the role of exercise interventions.Lipids in health and disease · 2025Review
- White Adipose Tissue in Obesity-Associated HFpEF: Insights From Mice and Humans.JACC. Basic to translational science · 2025Article
- The Primacy of Adipose Tissue Gene Expression and Plasma Lipidome in Cardiometabolic Disease in Persons With HIV.The Journal of infectious diseases · 2025Observational
- A Study on the Correlation Between Visceral Adiposity Index, Fatty Liver Index, and Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer: AKT3 and MAPK1 Cross Point in Obesity.Journal of obesity · 2024Article
- Association between age-adjusted visceral fat index (AVAI) and congestive heart failure: A cross-sectional study.Science progressArticle
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Authors and funding
23 authors.
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Abstract
objectiveThe objective of this study was to identify the transcriptional landscape of insulin resistance (IR) in subcutaneous adipose tissue (SAT) in humans across the spectrum of obesity.
methodsWe used SAT RNA sequencing in 220 individuals with metabolic phenotyping.
resultsWe identified a 35-gene signature with high predictive accuracy for homeostatic model of IR that was expressed across a variety of non-immune cell populations. We observed primarily "protective" IR associations for adipocyte transcripts and "deleterious" associations for macrophage transcripts, as well as a high concordance between SAT and visceral adipose tissue (VAT). Multiple SAT genes exhibited dynamic expression 5 years after weight loss surgery and with insulin stimulation. Using available expression quantitative trait loci in SAT and/or VAT, we demonstrated similar genetic effect sizes of SAT and VAT on type 2 diabetes and BMI.
conclusionsSAT is conventionally viewed as a metabolic buffer for lipid deposition during positive energy balance, whereas VAT is viewed as a dominant contributor to and prime mediator of IR and cardiometabolic disease risk. Our results implicate a dynamic transcriptional architecture of IR that resides in both immune and non-immune populations in SAT and is shared with VAT, nuancing the current VAT-centric concept of IR in humans.
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