Evidence map›Paper›PMID 38967120›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2024

Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties.

Joseph B Newton, Stephanie N Weiss, Courtney A Nuss, Christelle Darrieutort-Laffite, Jeremy D Eekhoff, David E Birk, Louis J Soslowsky

Abstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph B NewtonDepartment of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0009-0007-6420-9216
Stephanie N WeissDepartment of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Courtney A NussDepartment of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christelle Darrieutort-LaffiteDepartment of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jeremy D EekhoffDepartment of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David E BirkDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Louis J SoslowskyDepartment of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-9406-773X

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Training Program in Musculoskeletal ResearchT32AR007132 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Robert L Mauck, LOUIS J SOSLOWSKY · 1986 to 2026
$4.9M
Mouse Models for SLRP Roles in Tendon Aging and Impaired Healing in Aging TendonsR01AR068057 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SOSLOWSKY, LOUIS J · 2015 to 2019
$1.7M
NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR068057NIAMS NIH HHS R01AR068057NIAMS NIH HHS T32 AR007132NIAMS NIH HHS T32AR007132Penn Center for Musculoskeletal Disorders P30AR069619
6 · The paper itself

Abstract

Small leucine-rich proteoglycans, such as decorin and biglycan, play pivotal roles in collagen fibrillogenesis during development, healing, and aging in tendon. Previous work has shown that the absence of decorin and biglycan affects fibril shape and mechanical properties during tendon healing. However, the roles of decorin and biglycan in the healing process of aged tendons are unclear. Therefore the objective of this study was to evaluate the differential roles of decorin and biglycan during healing of patellar tendon injury in aged mice. Aged (300 days old) female Dcn

Indexed as

AgingBiglycanDecorinPatellar LigamentAnimalsBiomechanical PhenomenaCicatrixFemaleGene Knockdown TechniquesMiceTendon InjuriesWound HealingBgn protein, mouseBiglycanDcn protein, mouseDecorinagingbiglycandecorinsmall leucine‐rich proteoglycantendon

Identifiers

PMID38967120
PMCPMC11479833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.