ArticleBrain and behavior2024
Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic pain in mental disorders: An umbrella review of the prevalence, risk factors, and treatments across 957,168 people with mental disorders and 16,606,910 controls.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Associations between anxiety, somatic pain and sleep disturbances in major depressive disorder and chronic pain: A cross-sectional study with gender-specific insights.General psychiatry · 2026Article
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
- Bayesian-weighted Mendelian randomization reveals sleep apnea syndrome mediates the BMI-chronic pain link.Journal of thoracic disease · 2025Article
- Exploring the Mediating Role of Insomnia in the Relationship Between Fibromyalgia, Depression, and Anxiety in Lebanese Adults.Open access rheumatology : research and reviews · 2025Article
- Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain.Brain and behavior · 2024Article
- Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices.Nature and science of sleep · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDepression and chronic pain are significant contributors to the global burden of disease. Previous research has revealed complex relationships between these two conditions, which may be influenced by sleep quality. However, observational studies have limitations, including confounding factors and reverse causation. This study aims to explore the mediating effects of sleep on the relationship between depression and chronic pain using Mendelian randomization (MR).
methodsWe conducted a two-step, two-sample MR study using mediation analysis. We obtained major depressive disorder (MDD) Genome-Wide Association Studdies (GWAS) data from Wray et al.'s GWAS meta-analysis. Phenotypic data related to sleep were collected from the UK Biobank. Chronic pain data were obtained from the Finnish database.
resultsMR analysis revealed significant genetic associations between MDD and chronic localized pain [IVW: odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.16-1.38, p = 2.52 × 10
conclusionThis two-step MR analysis strengthens the evidence of genetic predictive associations between depression and chronic pain, highlighting the mediating roles of insomnia and short sleep duration. It further elucidates the specific roles of distinct sleep disorders, differentiating insomnia and short sleep duration from other sleep-related phenotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.