Evidence map›Paper›PMID 38966817›Full record

ArticleRSC advances2024

Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD-ACE2 and TMPRRS2 proteins.

Mariana J Shayo, Baraka Samwel, Daniel M Shadrack, Joel Cassel, Joseph M Salvino, Luis J Montaner, Geradius Deogratias, Ian Tietjen, Lucy Kiruri, Samson Hilonga and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mariana J ShayoDepartment of Biological and Pre-clinical Studies, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences P.O.Box 65001 Dar es Salaam Tanzania.ORCID https://orcid.org/0000-0002-7756-8142
Baraka SamwelDepartment of Natural Products, Institute of Traditional Medicines, Muhimbili University of Health and Allied Sciences P.O.Box 65001 Dar es Salaam Tanzania.
Daniel M ShadrackDepartment of Chemistry, Faculty of Natural and Applied Sciences, St. John's University of Tanzania P.O.Box 47 Dodoma Tanzania.
Joel CasselThe Wistar Institute 3601 Spruce Street Philadelphia PA 19104 USA.ORCID https://orcid.org/0000-0001-8465-8739
Joseph M SalvinoThe Wistar Institute 3601 Spruce Street Philadelphia PA 19104 USA.ORCID https://orcid.org/0000-0002-2184-5980
Luis J MontanerThe Wistar Institute 3601 Spruce Street Philadelphia PA 19104 USA.ORCID https://orcid.org/0000-0001-5799-6759
Geradius DeogratiasChemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam P.O.Box 35061 Dar es Salaam Tanzania dgeradius@udsm.ac.tz.ORCID https://orcid.org/0000-0002-2941-8668
Ian TietjenThe Wistar Institute 3601 Spruce Street Philadelphia PA 19104 USA.
Lucy KiruriKenyata University, Department of Chemistry P.O.Box 43844-00100 Nairobi Kenya.
Samson HilongaDepartment of Medical Botany, Plant Breeding and Agronomy, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences P.O.Box 65001 Dar es Salaam Tanzania.
Ester InnocentDepartment of Biological and Pre-clinical Studies, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences P.O.Box 65001 Dar es Salaam Tanzania.

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
NCI NIH HHS P30 CA010815
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) has spread worldwide with severe health, social, and economic repercussions. Although vaccines have significantly reduced the severity of symptoms and deaths, alternative medications derived from natural products (NPs) are vital to further decrease fatalities, especially in regions with low vaccine uptake. When paired with the latest computational developments, NPs, which have been used to cure illnesses and infections for thousands of years, constitute a renewed resource for drug discovery. In the present report, a combination of computational and

Identifiers

PMID38966817
PMCPMC11223729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.