Evidence map›Paper›PMID 38966813›Full record

ArticleRSC advances2024

Cascade enzymatic synthesis of a statin side chain precursor - the role of reaction engineering in process optimization.

Martina Sudar, Nevena Milčić, Morana Česnik Katulić, Anna Szekrenyi, Karel Hernández, Melinda Fekete, Rainer Wardenga, Maja Majerić Elenkov, Yuyin Qi, Simon Charnock and 4 more

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Martina SudarUniversity of Zagreb Faculty of Chemical Engineering and Technology Savska c. 16 HR-10000 Zagreb Croatia msudar@fkit.unizg.hr zfindrik@fkit.unizg.hr +385 1 4597 133 +385 1 4597 157 +385 1 4597 101.ORCID https://orcid.org/0000-0002-6734-1024
Nevena MilčićUniversity of Zagreb Faculty of Chemical Engineering and Technology Savska c. 16 HR-10000 Zagreb Croatia msudar@fkit.unizg.hr zfindrik@fkit.unizg.hr +385 1 4597 133 +385 1 4597 157 +385 1 4597 101.
Morana Česnik KatulićUniversity of Zagreb Faculty of Chemical Engineering and Technology Savska c. 16 HR-10000 Zagreb Croatia msudar@fkit.unizg.hr zfindrik@fkit.unizg.hr +385 1 4597 133 +385 1 4597 157 +385 1 4597 101.
Anna SzekrenyiTechnische Universität Darmstadt Peter-Grünberg-Straße 4 64287 Darmstadt Germany.
Karel HernándezInstitute of Advanced Chemistry of Catalonia, Biotransformation and Bioactive Molecules Group, IQAC-CSIC Jordi Girona 18-26 08034 Barcelona Spain.
Melinda FeketeEnzymicals AG Walther-Rathenau-Straße 49b 17489 Greifswald Germany.
Rainer WardengaEnzymicals AG Walther-Rathenau-Straße 49b 17489 Greifswald Germany.
Maja Majerić ElenkovRuđer Bošković Institute Bijenička cesta 54 HR-10 000 Zagreb Croatia.
Yuyin QiProzomix Ltd Haltwhistle Northumberland NE49 9HA UK.
Simon CharnockProzomix Ltd Haltwhistle Northumberland NE49 9HA UK.
Đurđa Vasić-RačkiUniversity of Zagreb Faculty of Chemical Engineering and Technology Savska c. 16 HR-10000 Zagreb Croatia msudar@fkit.unizg.hr zfindrik@fkit.unizg.hr +385 1 4597 133 +385 1 4597 157 +385 1 4597 101.
Wolf-Dieter FessnerTechnische Universität Darmstadt Peter-Grünberg-Straße 4 64287 Darmstadt Germany.ORCID https://orcid.org/0000-0002-9787-0752
Pere ClapésInstitute of Advanced Chemistry of Catalonia, Biotransformation and Bioactive Molecules Group, IQAC-CSIC Jordi Girona 18-26 08034 Barcelona Spain.ORCID https://orcid.org/0000-0001-5541-4794
Zvjezdana Findrik BlaževićUniversity of Zagreb Faculty of Chemical Engineering and Technology Savska c. 16 HR-10000 Zagreb Croatia msudar@fkit.unizg.hr zfindrik@fkit.unizg.hr +385 1 4597 133 +385 1 4597 157 +385 1 4597 101.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins are an important class of drugs used to lower blood cholesterol levels and are often used to combat cardiovascular disease. In view of the importance of safe and reliable supply and production of statins in modern medicine and the global need for sustainable processes, various biocatalytic strategies for their synthesis have been investigated. In this work, a novel biocatalytic route to a statin side chain precursor was investigated in a one-pot cascade reaction starting from the protected alcohol

Identifiers

PMID38966813
PMCPMC11223575

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.