Evidence map›Paper›PMID 38966778›Full record

ArticleDiscovery immunology2024

Elevated type-17 cytokines are present in axial spondyloarthritis stool.

India Brough, Kelsey Thompson, Ciara Latore, Frank Penkava, Chelsea Regan, Claire Pearson, Hui Shi, Anna Ridley, Davide Simone, Lilian Lam and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discovery immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

India BroughNDORMS, Oxford University, Oxford, UK.ORCID https://orcid.org/0000-0001-7211-8727
Kelsey ThompsonChan School of Public Health, Harvard University, Boston, MA, USA.
Ciara LatoreNDORMS, Oxford University, Oxford, UK.
Frank PenkavaNDORMS, Oxford University, Oxford, UK.
Chelsea ReganInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Claire PearsonNDORMS, Oxford University, Oxford, UK.
Hui ShiNDORMS, Oxford University, Oxford, UK.
Anna RidleyNDORMS, Oxford University, Oxford, UK.
Davide SimoneNDORMS, Oxford University, Oxford, UK.
Lilian LamNDORMS, Oxford University, Oxford, UK.
Samuel BullersNDORMS, Oxford University, Oxford, UK.
Caroline MoussaNDORMS, Oxford University, Oxford, UK.
Rachel FeeneyNDORMS, Oxford University, Oxford, UK.
Inflammatory Arthritis Microbiome Consortium (IAMC) Investigators Group
Mohammed H Al-MossawiNDORMS, Oxford University, Oxford, UK.
Fiona PowrieNDORMS, Oxford University, Oxford, UK.
Stephen YoungInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-6355-3361
Curtis HuttenhowerChan School of Public Health, Harvard University, Boston, MA, USA.ORCID https://orcid.org/0000-0002-1110-0096
Paul BownessNDORMS, Oxford University, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Axial spondyloarthritis (axSpA) is characterized by type-17 immune-driven joint inflammation, and intestinal inflammation is present in around 70% of patients. In this study, we asked whether axSpA stool contained Th17-associated cytokines and whether this related to systemic Th17 activation. We measured stool cytokine and calprotectin levels by ELISA and found that patients with axSpA have increased stool IL-17A, IL-23, GM-CSF, and calprotectin. We further identified increased levels of circulating IL-17A+ and IL-17F+ T-helper cell lymphocytes in patients with axSpA compared to healthy donors. We finally assessed stool metabolites by unbiased nuclear magnetic resonance spectroscopy and found that multiple stool amino acids were negatively correlated with stool IL-23 concentrations. These data provide evidence of type-17 immunity in the intestinal lumen, and suggest its association with microbial metabolism in the intestine.

Indexed as

Amino acidsAxSpAIL-17IL-23MicrobiomeTh17

Identifiers

PMID38966778
PMCPMC11222980

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.