Evidence map›Paper›PMID 38966453›Full record

ArticleCureus2024

Hemophagocytic Lymphohistiocytosis: A Case Series From a Tertiary State Hospital in Malaysia and a Review of Current Literature.

Jing Yi Khaw, Wee Fu Gan, Hwee Cheng Chong, Ngee Siang Lau, Wan Aswani Wan Yusof

Abstract read
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing Yi KhawMedical Department, Hospital Melaka, Melaka, MYS.
Wee Fu GanInfectious Diseases Department, Hospital Melaka, Melaka, MYS.
Hwee Cheng ChongMedical Department, Hospital Melaka, Melaka, MYS.
Ngee Siang LauHematology Department, Hospital Ampang, Ampang, MYS.
Wan Aswani Wan YusofPathology and Laboratory Medicine Department, Hospital Melaka, Melaka, MYS.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHemophagocytic lymphohistiocytosis (HLH) is a lethal emergency. Delays in diagnosis and treatment are detrimental to the health of patients. Classical clinical manifestations of HLH include fever, cytopenia, liver dysfunction, central nervous system involvement, and coagulopathy.

methodsWe report seven cases of secondary HLH in adults diagnosed from a total of 1200 bone marrow aspiration and trephine biopsy (BMAT) examinations in our center, with various presentations and underlying triggers including infection, malignancy, and autoimmune disease.

resultsHLH can present with non-specific signs and symptoms.

conclusionEarly recognition of HLH is crucial to enable the commencement of therapy as early as possible to prevent mortality resulting from multi-organ failure.

Indexed as

adult onset still's diseasebmathlhhscorelymphoma

Identifiers

PMID38966453
PMCPMC11223718

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.