Simple dynamic cell culture system reduces recording noise in microelectrode array recordings.

Darius Hoven, Misaki Inaoka, Reece McCoy, Aimee Withers, Róisín M Owens, George G Malliaras

Abstract read

In one paragraph

Article in MRS communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Darius HovenElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA UK.ORCID 0000-0003-3814-2699

Misaki InaokaElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA UK.ORCID 0000-0002-4869-2574

Reece McCoyDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS UK.ORCID 0000-0001-9086-7019

Aimee WithersDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS UK.

Róisín M OwensDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS UK.ORCID 0000-0001-7856-2108

George G MalliarasElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA UK.ORCID 0000-0002-4582-8501

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microelectrode arrays (MEAs) have applications in drug discovery, toxicology, and basic research. They measure the electrophysiological response of tissue cultures to quantify changes upon exposure to biochemical stimuli. Unfortunately, manual addition of chemicals introduces significant noise in the recordings. Here, we report a simple-to-fabricate fluidic system that addresses this issue. We show that cell cultures can be successfully established in the fluidic compartment under continuous flow conditions and that the addition of chemicals introduces minimal noise in the recordings. This dynamic cell culture system represents an improvement over traditional tissue culture wells used in MEAs, facilitating electrophysiology measurements. Graphical abstract:

Indexed as

BioelectronicBiomedicalDevicesFluidicsMicroelectronicsMicroscale

Identifiers

PMID38966401

DOI10.1557/s43579-024-00554-3

PMCPMC11219396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.