ArticleChemical science2024
Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery.
Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- A state-switchable TADF macrocycle for multi-analyte sensing and hydrogen gas-driven emission enhancement.Communications chemistry · 2026Article
- Coordination sphere interactions drive isomer selection in heteroleptic Pd(ii) cages with low-symmetry ligands.Chemical science · 2025Article
- Dissecting the Effects of Cage Structure in the Catalytic Activation of Imide Chlorenium-Ion Donors.Journal of the American Chemical Society · 2025Article
- Synthesis of a PdInternational journal of molecular sciences · 2024Article
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Authors and funding
6 authors.
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Abstract
Molecular cages are three-dimensional supramolecular structures that completely wrap guest molecules by encapsulation. We describe a rare comparative study between a metallo-organic cage and a fully organic analogous system, obtained by hydrazone bond formation self-assembly. Both cages are able to encapsulate the anticancer drug doxorubicin, with the organic cage forming a 1 : 1 inclusion complex with μM affinity, whereas the metallo-organic host experiences disassembly by interaction with the drug. Stability experiments reveal that the ligands of the metallo-organic cage are displaced in buffer at neutral, acidic, and basic pH, while the organic cage only disassembles under acidic conditions. Notably, the organic cage also shows minimal cell toxicity, even at high doses, whilst the doxorubicin-cage complex shows
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