Evidence map›Paper›PMID 38966003›Full record

ArticleAdvanced functional materials2024

4D Printed Protein-AuNR Nanocomposites with Photothermal Shape Recovery.

Siwei Yu, Naroa Sadaba, Eva Sanchez-Rexach, Shayna L Hilburg, Lilo D Pozzo, Gokce Altin-Yavuzarslan, Luis M Liz-Marzán, Dorleta Jimenez de Aberasturi, Haritz Sardon, Alshakim Nelson

Abstract read
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Designing the Next Generation of Biomaterials through Nanoengineering.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  5. Stimuli-responsive hybrid materials for 4DMaterials today. Bio · 2025
    Review
  6. Article
  7. Strain learning in protein-based mechanical metamaterials.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siwei YuDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.
Naroa SadabaDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; POLYMAT and Department of Polymers and Advanced Materials: Physics, Chemistry and Technology, Faculty of Chemistry, University of Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain.
Eva Sanchez-RexachDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA; POLYMAT and Department of Polymers and Advanced Materials: Physics, Chemistry and Technology, Faculty of Chemistry, University of Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain.
Shayna L HilburgDepartment of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
Lilo D PozzoDepartment of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
Gokce Altin-YavuzarslanMolecular Engineering and Sciences Institute, University of Washington, Seattle, WA, 98195, USA.
Luis M Liz-MarzánCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastián, Spain; Biomedical Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 20014, Donostia-San Sebastián, Spain; Ikerbaque, Basque Foundation for Science, 48009 Bilbao, Spain.
Dorleta Jimenez de AberasturiCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastián, Spain; Biomedical Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 20014, Donostia-San Sebastián, Spain; Ikerbaque, Basque Foundation for Science, 48009 Bilbao, Spain.
Haritz SardonPOLYMAT and Department of Polymers and Advanced Materials: Physics, Chemistry and Technology, Faculty of Chemistry, University of Basque Country UPV/EHU, Donostia-San Sebastián 20018, Spain.
Alshakim NelsonDepartment of Chemistry, University of Washington, Seattle, WA 98195, USA.

Funding

3D Printed Engineered Living Materials for Drug DeliveryR21EB031256 · NIBIB · UNIVERSITY OF WASHINGTON · PI NELSON, ALSHAKIM · 2022 to 2024
$589k
NIBIB NIH HHS R21 EB031256
6 · The paper itself

Abstract

4D printing is the 3D printing of objects that change chemically or physically in response to an external stimulus over time. Photothermally responsive shape memory materials are attractive for their ability to undergo remote activation. While photothermal methods using gold nanorods (AuNRs) have been used for shape recovery, 3D patterning of these materials into objects with complex geometries using degradable materials has not been addressed. Here, we report on the fabrication of 3D printed shape memory bioplastics with photo-activated shape recovery. Protein-based nanocomposites based on bovine serum albumin (BSA), poly (ethylene glycol) diacrylate and gold nanorods were developed for vat photopolymerization. These 3D printed bioplastics were mechanically deformed under high loads, and the proteins served as mechanoactive elements that unfolded in an energy-dissipating mechanism that prevented fracture of the thermoset. The bioplastic object maintained its metastable shape-programmed state under ambient conditions. Subsequently, up to 99% shape recovery was achieved within 1 min of irradiation with near-infrared light. Mechanical characterization and small angle X-ray scattering (SAXS) analysis suggest that the proteins mechanically unfold during the shape programming step and may refold during shape recovery. These composites are promising materials for the fabrication of biodegradable shape-morphing devices for robotics and medicine.

Indexed as

3D printingGold NanorodPhotothermalProteinShape recovery

Identifiers

PMID38966003
PMCPMC11221775

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.