Evidence map›Paper›PMID 38965878›Full record

ArticleJournal of cardiovascular electrophysiology2024

Association between high-density mapping of atypical atrial flutter, clinical outcomes and healthcare utilization.

Joshua Sink, Kasen Culler, Lakshmi Uppalapati, Nicola Lancki, Graham Peigh, Graham Lohrmann, Mahmoud Elsayed, Herman Carneiro, Jayson Baman, Anna Pfenniger and 8 more

Abstract readComparative Study
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joshua SinkDepartment of Internal Medicine, Northwestern University, Chicago, Illinois, USA.
Kasen CullerDepartment of Internal Medicine, Northwestern University, Chicago, Illinois, USA.
Lakshmi UppalapatiDepartment of Internal Medicine, Baylor University, Houston, Texas, USA.
Nicola LanckiDepartment of Preventative Medicine, Northwestern University, Chicago, Illinois, USA.
Graham PeighDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Graham LohrmannDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Mahmoud ElsayedDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Herman CarneiroDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Jayson BamanDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Anna PfennigerDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Kaustubha D PatilDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0003-4592-1383
Nishant VermaDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0003-4817-6614
Rishi AroraDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-0725-4332
Susan S KimDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Alexandru B ChicosDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-0291-4434
Albert C LinDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-9134-8333
Bradley P KnightDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.
Rod S PassmanDivision of Cardiology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-8718-1534

Funding

New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial FibrillationR35HL161249 · NHLBI · UNIVERSITY OF CHICAGO · PI Rishi Arora · 2022 to 2026
$5.1M
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heartR01HL152712 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI, ZHAO, MING · 2021 to 2024
$3.0M
NHLBI NIH HHS R01 HL152712NHLBI NIH HHS R35 HL161249
6 · The paper itself

Abstract

backgroundSuccess of atypical atrial flutter (AAFL) ablation has historically been limited by difficulty mapping the complex re-entrant circuits involved. While high-density (HD) mapping has become commonplace in clinical practice, there are limited data on outcomes of HD versus non-HD mapping for AAFL ablation.

objectiveTo compare clinical outcomes and healthcare utilization using HD mapping versus non-HD mapping for AAFL ablation.

methodsRetrospective analysis of all AAFL procedures between 2005 and 2022 at an academic medical center was conducted. Procedures utilizing a 16-electrode HD Grid catheter and Precision mapping system were compared to procedures using prior generation 10-20 electrode spiral catheters and the Velocity system (Abbott, IL). Cox regression models and Poisson regression models were utilized to examine procedural and healthcare utilization outcomes. Models were adjusted for left ventricular ejection fraction, CHA

resultsThere were 108 patients (62% HD mapping) included in the analysis. Baseline clinical characteristics were similar between groups. Use of HD mapping was associated with a higher rate of AAFL circuit delineation (92.5% vs. 76%; p = .014) and a greater adjusted procedure success rate, defined as non-inducibility at procedure end, (aRR (95% CI) 1.26 (1.02-1.55) p = .035) than non-HD mapping. HD mapping was also associated with a lower rate of ED visits (aIRR (95% CI) 0.32 (0.14-0.71); p = .007) and hospitalizations (aIRR (95% CI) 0.32 (0.14-0.68); p = .004) for AF/AFL/HF through 1 year. While there was a lower rate of recurrent AFL through 1 year among HD mapping cases (aHR (95% CI) 0.60 (0.31-1.16) p = .13), statistical significance was not met likely due to the low sample size and higher rate of ambulatory rhythm monitoring in the HD group (61% vs. 39%, p = .025).

conclusionCompared to non-HD mapping, AAFL ablation with HD mapping is associated with improvements in the ability to define the AAFL circuit, greater procedural success, and a reduction in the number of ED visits and hospitalization for AF/AFL/HF.

Indexed as

Action PotentialsAtrial FlutterCatheter AblationElectrophysiologic Techniques, CardiacPredictive Value of TestsAgedCardiac CathetersFemaleHeart RateHumansMaleMiddle AgedPatient Acceptance of Health CareRecurrenceRetrospective StudiesRisk Factorsatypical atrial flutterhealthcare utilizationhigh density mapping

Identifiers

PMID38965878
PMCPMC12981567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.