Evidence map›Paper›PMID 38965872›Full record

ArticleInfluenza and other respiratory viruses2024

Molecular Epidemiology of Human Parainfluenza Virus Type 3 in Children With Acute Respiratory Tract Infection in Hangzhou.

Ya-Jun Guo, Lin Li, Qin-Rui Lai, Ying-Shuo Wang, Wei Li

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Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ya-Jun GuoDepartment of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lin LiDepartment of Infectious Diseases, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), National Regional Medical Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Qin-Rui LaiDepartment of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ying-Shuo WangDepartment of Respiratory, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wei LiDepartment of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0001-7501-5707

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince the outbreak of COVID-19, China has undertaken a variety of preventative and control measures, effectively reducing the incidence of numerous infectious diseases among the pediatric population in Hangzhou. We aim to investigate the genetic and epidemiological characteristics of Human parainfluenza virus-3 (HPIV-3) in pediatric patients during this period.

methodsA total of 1442 pharyngeal swab samples were collected from outpatients and inpatients with a diagnosis of acute respiratory tract infections (ARTIs) from November 2020 to March 2021. HPIV-3 was detected by quantitative real time polymerase chain reaction (qRT-PCR). The L gene of HPIV-3 positive samples was amplified and sequenced.

resultsAmong 1442 children with ARTI, the positive rate of HPIV-3 was 7.07% (102/1442). The positive detection rate was the highest in the 6-month to 1-year age group. Coinfection was observed in 36 HPIV-3-positive samples (35.29%, 36/102), and adenovirus (ADV) was the most common coinfecting virus (63.89%, 23/36). The L gene of 48 HPIV-3 positive samples was sequenced. The nucleotide sequence analysis showed high consistency (92.10%-99.40%), and all strains belonged to C3a.

conclusionsDuring study periods, the positive detection rate of HPIV-3 among children is high, and the highest proportion of coinfection was observed in HPIV-3 mixed ADV infection. Phylogenetic analysis revealed that the nucleotide sequence of the L gene of HPIV-3 was highly consistent, and the main epidemic strain in this area was the C3a subtype.

Indexed as

Molecular EpidemiologyParainfluenza Virus 3, HumanPhylogenyRespiratory Tract InfectionsRespirovirus InfectionsAdolescentChildChild, PreschoolChinaCoinfectionFemaleHumansInfantInfant, NewbornMaleacute respiratory tract infectionchildrenCOVID‐19human parainfluenza virus type 3L gene

Identifiers

PMID38965872
PMCPMC11224502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.