ArticleCardiovascular diabetology2024
Artificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global research landscape and emerging frontiers of ultra-processed food intake and cardiometabolic health: a bibliometric and knowledge-mapping analysis (2015-2025).Frontiers in nutrition · 2026Pooled it
- Health behaviors to prevent cardiovascular risk: a systematic review.BMC cardiovascular disorders · 2025Pooled it
- Role of Life's Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants.Journal of global health · 2026Article
- Associations between female sex-specific risk factors and cardiometabolic multimorbidity: evidence from the UK Biobank cohort study.BMC public health · 2026Article
- Artificial sweeteners and risk of cardiometabolic outcomes and mortality: a systematic review and meta-analysis.Nutrition research and practice · 2026Review
- Artificial Sweeteners and Gut Microbiota: Mechanistic Insights and Implications for Metabolic Health.Current nutrition reports · 2026Review
- Soda Sugar Supertaxes Pave the Way for a Large Increase in Consumption of Sweeteners and Its Long-Term Effects.Obesity (Silver Spring, Md.) · 2026Article
- Genotoxicity of Artificial Sweetener Combinations: An Integrated Drosophila melanogaster SMART Assay and Computational Modeling Approach.Molecular genetics and genomics : MGG · 2026Article
- Effects of artificial sweeteners on coronary heart disease: A 2-way 2-sample Mendelian randomization study and mediation analysis.Medicine · 2026Article
- Association between neuroticism, genetic susceptibility, and peripheral artery disease risk: a prospective study in UK Biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Investigating the relationship between taste perception of artificial sweeteners and cancer risk.Public health nutrition · 2026Article
- Article
- Association of sugar-sweetened, artificially sweetened, and unsweetened tea with all-cause and cause-specific mortality: a prospective cohort study in UK biobank.BMC public health · 2025Article
- Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis.Scientific reports · 2025Article
- Artificial Sweeteners and Cardiovascular Risk in Hungary: Beyond Traditional Risk Factors.Journal of clinical medicine · 2025Article
- Overnutrition in the Elderly Population: Socio-Demographic and Behavioral Risk Factors in Hungary.Nutrients · 2025Article
- Lifestyle, nutritional, and health influences on consumption of artificially-sweetened beverages in educated urban populations.PloS one · 2025Article
- Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants.Frontiers in public health · 2025Article
- Cardiovascular health and cancer mortality: evidence from US NHANES and UK Biobank cohort studies.BMC medicine · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundArtificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascular disease (CVD). We aimed to extensively assess the association and subgroup variability between artificial sweeteners and CVD and CVD mortality in the UK Biobank cohort, and further investigate the modification effects of genetic susceptibility and the mediation role of type 2 diabetes mellitus (T2DM).
methodsThis study included 133,285 participants in the UK Biobank who were free of CVD and diabetes at recruitment. Artificial sweetener intake was obtained from repeated 24-hour diet recalls. Cox proportional hazard models were used to estimate HRs. Genetic predisposition was estimated using the polygenic risk score (PRS). Furthermore, time-dependent mediation was performed.
resultsIn our study, artificial sweetener intake (each teaspoon increase) was significantly associated with an increased risk of incident overall CVD (HR1.012, 95%CI: 1.008,1.017), coronary artery disease (CAD) (HR: 1.018, 95%CI: 1.001,1.035), peripheral arterial disease (PAD) (HR: 1.035, 95%CI: 1.010,1.061), and marginally significantly associated with heart failure (HF) risk (HR: 1.018, 95%CI: 0.999,1.038). In stratified analyses, non-whites were at greater risk of incident overall CVD from artificial sweetener. People with no obesity (BMI < 30 kg/m
conclusionsOur findings suggest significant or marginally significant associations between artificial sweeteners and CVD and its subtypes (CAD, PAD, and HF). The associations are independent of genetic predisposition and are mediated primarily by T2DM. Therefore, the large-scale application of artificial sweeteners should be prudent, and the responses of individuals with different characteristics to artificial sweeteners should be better characterized to guide consumers' artificial sweeteners consumption behavior.
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