ArticleScientific reports2024
An in-vivo treatment monitoring system for ion-beam radiotherapy based on 28 Timepix3 detectors.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Out-of-beam artifact suppression in charged nuclear fragment based carbon-ion radiotherapy monitoring.Medical physics · 2026Article
- The Role of Molecular Imaging in Ion Beam Therapy.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Detection of an internal density change in an anthropomorphic head phantom via tracking of charged nuclear fragments in carbon-ion radiotherapy.Medical physics · 2025Article
- Feasibility study of 4D-online monitoring of density gradients induced by lung cancer treatment using carbon ions.Frontiers in oncology · 2025Article
- Experimental validation of a FLUKA Monte Carlo simulation for carbon-ion radiotherapy monitoring via secondary ion tracking.Medical physics · 2024Article
- First experimental verification of prompt gamma imaging with carbon ion irradiation.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Ion-beam radiotherapy is an advanced cancer treatment modality offering steep dose gradients and a high biological effectiveness. These gradients make the therapy vulnerable to patient-setup and anatomical changes between treatment fractions, which may go unnoticed. Charged fragments from nuclear interactions of the ion beam with the patient tissue may carry information about the treatment quality. Currently, the fragments escape the patient undetected. Inter-fractional in-vivo treatment monitoring based on these charged nuclear fragments could make ion-beam therapy safer and more efficient. We developed an ion-beam monitoring system based on 28 hybrid silicon pixel detectors (Timepix3) to measure the distribution of fragment origins in three dimensions. The system design choices as well as the ion-beam monitoring performance measurements are presented in this manuscript. A spatial resolution of
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