Evidence map›Paper›PMID 38965251›Full record

ArticleScientific reports2024

Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.

Hewang Lee, Bibhas Amatya, Van Anthony M Villar, Laureano D Asico, Jin Kwon Jeong, Jun Feranil, Shaun C Moore, Xiaoxu Zheng, Michael Bishop, Jerald P Gomes and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hewang Lee *Division of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA. lih@gwu.edu.
Bibhas Amatya *Division of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Van Anthony M VillarDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Laureano D AsicoDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Jin Kwon JeongDepartment of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, 20052, USA.
Jun FeranilDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Shaun C MooreDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Xiaoxu ZhengDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Michael BishopDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Jerald P GomesDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Jacob PolzinDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Noah SmeriglioDepartment of Chemistry, Columbian College of Arts and Sciences, The George Washington University, Washington, DC, 20052, USA.
Pedro A S Vaz de CastroDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Ines ArmandoDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.
Robin A FelderDepartment of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA, 22908.5, USA.
Ling HaoDepartment of Chemistry, Columbian College of Arts and Sciences, The George Washington University, Washington, DC, 20052, USA.
Pedro A JoseDivision of Renal Diseases and Hypertension, Department of Medicine, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, NW, Washington, DC, 20052, USA.

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JOSE, PEDRO A. · 2004 to 2020
$31.8M
RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 1987 to 2020
$7.4M
Renal Dopamine Receptor & RegulationR37HL023081 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 2007 to 2016
$4.3M
D2 receptor variation and renal dysfunctionR01DK134574 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Pedro A. Jose · 2023 to 2026
$2.8M
Lipid rafts, dopamine 1 receptor, and hypertensionR01DK119652 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JOSE, PEDRO A. · 2020 to 2023
$2.6M
NHLBI NIH HHS P01 HL074940NHLBI NIH HHS R37 HL023081NIDDK NIH HHS R01 DK039308NIDDK NIH HHS R01 DK119652NIDDK NIH HHS R01 DK134574NIH HHS P01HL074940
6 · The paper itself

Abstract

The kidney and brain play critical roles in the regulation of blood pressure. Neuropeptide FF (NPFF), originally isolated from the bovine brain, has been suggested to contribute to the pathogenesis of hypertension. However, the roles of NPFF and its receptors, NPFF-R1 and NPFF-R2, in the regulation of blood pressure, via the kidney, are not known. In this study, we found that the transcripts and proteins of NPFF and its receptors, NPFF-R1 and NPFF-R2, were expressed in mouse and human renal proximal tubules (RPTs). In mouse RPT cells (RPTCs), NPFF, but not RF-amide-related peptide-2 (RFRP-2), decreased the forskolin-stimulated cAMP production in a concentration- and time-dependent manner. Furthermore, dopamine D1-like receptors colocalized and co-immunoprecipitated with NPFF-R1 and NPFF-R2 in human RPTCs. The increase in cAMP production in human RPTCs caused by fenoldopam, a D1-like receptor agonist, was attenuated by NPFF, indicating an antagonistic interaction between NPFF and D1-like receptors. The renal subcapsular infusion of NPFF in C57BL/6 mice decreased renal sodium excretion and increased blood pressure. The NPFF-mediated increase in blood pressure was prevented by RF-9, an antagonist of NPFF receptors. Taken together, our findings suggest that autocrine NPFF and its receptors in the kidney regulate blood pressure, but the mechanisms remain to be determined.

Indexed as

Autocrine CommunicationBlood PressureCyclic AMPOligopeptidesSignal TransductionAnimalsHumansKidneyKidney Tubules, ProximalMaleMiceMice, Inbred C57BLReceptors, Dopamine D1Receptors, NeuropeptideCyclic AMPneuropeptide FF receptorOligopeptidesphenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamideReceptors, Dopamine D1Receptors, NeuropeptideBlood pressureBrainDopamine D1-like receptorKidneyNeuropeptide FF

Identifiers

PMID38965251
PMCPMC11224344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.