Evidence map›Paper›PMID 38965122›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

Associations between new obesity indices and abnormal bone density in type 2 diabetes mellitus patients.

Xia Deng, Xunan Wu, Ziyan Sun, Qiaoyan Liu, Guoyue Yuan

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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4 citing papers in PubMed.

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5 · Who and what money

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5 authors.

Xia Deng *Department of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China.
Xunan Wu *Department of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China.
Ziyan Sun *Department of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China.
Qiaoyan LiuDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China.
Guoyue YuanDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China. yuanguoyue@ujs.edu.cn.

Funding

Affiliated Hospital of Jiangsu University Beigu Talent Cultivation Plan Project BGYCB202206Affiliated Hospital of Jiangsu University Doctoral Initiation Fund Project jdfyRC2021005Key R&D Plan Social Development Project of Jiangsu Province SBE2023741128National Natural Science Foundation of China 82300903Natural Science Foundation of Jiangsu Province SBK2023022865Projects from Social Development of Zhenjiang SH2023029sixth phase 333 second level talent training project of Jiangsu Province BRA2022008
6 · The paper itself

Abstract

The clinical data analysis found that, compared with the traditional obesity index, the waist-weight ratio (WWR) has more advantages in predicting abnormal bone mineral density in subjects with type 2 diabetes. WWR may serve as a new predictive indicator for osteoporosis in T2DM patients. PURPOSE: This study was designed to explore the correlation between obesity-related indices and bone mineral density (BMD) and its influencing factors in type 2 diabetes mellitus (T2DM) patients.

methodsA total of 528 patients with type 2 diabetes were recruited. Glucose tolerance, insulin stimulation, and blood biochemical tests were conducted on all participants. All subjects underwent dual-energy X-ray bone density testing and were grouped based on the bone density results.

resultsCompared with those in the normal BMD group, the waist-to-body weight ratio (WWR) and weight-adjusted-waist index (WWI) in the osteopenia and osteoporosis groups were significantly greater, while body mass index (BMI) was significantly lower (P < 0.05). The logistic regression results showed that the WWR, WWI, and BMI were independently correlated with abnormal BMD in T2DM patients (P < 0.05). WWR and the WWI were negatively correlated with the T-value of bone density in various parts of the body, while BMI was positively correlated with the T-value of bone density (P < 0.05). The area under the working characteristic curve (AUC) for T2DM patients with abnormal bone mass predicted by the WWR [0.806, 95% CI = (0.770-0.843), P < 0.001] was greater than that for patients with other obesity indicators, such as the WWI and BMI.

conclusionWe found a positive correlation between the WWR and bone density in T2DM patients. Compared with other obesity indicators, such as BMI and WWI, the WWR has a stronger discriminative ability for T2DM patients with abnormal bone density. Therefore, more attention should be given to the WWR in T2DM patients.

Indexed as

Bone DensityDiabetes Mellitus, Type 2ObesityAdultAgedBody WeightCross-Sectional StudiesHumansMaleMiddle AgedWaist CircumferenceObesity indexOsteoporosisType 2 diabetes mellitus

Identifiers

PMID38965122

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.