Evidence map›Paper›PMID 38964886›Full record

ArticleInternational journal of spine surgery2024

Impact of Targeted Systemic Therapy and Radiotherapy on Patients Undergoing Spine Surgery for Metastatic Renal Cell Carcinoma.

Hani Chanbour, Jeffrey W Chen, Gabriel A Bendfeldt, Lakshmi Suryateja Gangavarapu, Matthew E LaBarge, Mahmoud Ahmed, Iyan Younus, Soren Jonzzon, Steven G Roth, Silky Chotai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of spine surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Finite element validation and short-term clinical outcomes of robot-assisted percutaneous microwave ablation plus cement augmentation and sacroiliac screw fixation for upper sacral (S1-S2) metastases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hani ChanbourDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey W ChenVanderbilt University, School of Medicine, Nashville, TN, USA.
Gabriel A BendfeldtVanderbilt University, School of Medicine, Nashville, TN, USA.
Lakshmi Suryateja GangavarapuVanderbilt University, School of Medicine, Nashville, TN, USA.
Matthew E LaBargeDepartment of Orthopedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Mahmoud AhmedDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Iyan YounusDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Soren JonzzonDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Steven G RothDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Silky ChotaiDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Brian I RiniDivision of Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Leo Y LuoDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Amir M AbtahiDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Byron F StephensDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Scott L ZuckermanDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA scott.zuckerman@vumc.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients undergoing spine surgery for renal cell carcinoma (RCC), we sought to: (1) describe patterns of postoperative targeted systemic therapy and radiotherapy (RT), (2) compare perioperative outcomes among those treated with targeted systemic therapy to those without, and (3) evaluate the impact of targeted systemic therapy and/or RT on overall survival (OS) and local recurrence (LR).

methodsA single-institution, retrospective cohort study of patients undergoing spine surgery for metastatic RCC from 2010 to 2021 was undertaken. Treatment groups were RT alone, targeted systemic therapy alone, dual therapy consisting of RT and targeted systemic therapy, and neither therapy. Multivariable Cox regression controlled for age, race, sex, insurance, and preoperative targeted systemic therapy.

resultsForty-nine patients underwent spine surgery for RCC. Postoperatively, 4 patients (8%) received RT alone, 19 (38.8%) targeted systemic therapy alone, 12 (24.5%) dual therapy, and 13 (28.6%) neither. All groups were similar in demographics, preoperative Karnofsky Performance Score (

conclusionIn patients undergoing metastatic spine surgery for RCC, postoperative dual therapy demonstrated significantly higher 1-year survival and OS compared with other therapies. CLINICAL RELEVANCE: Multidisciplinary management of metastatic RCC is necessary to ensure timely implementation of targeted systemic therapy and RT to improve outcomes. LEVEL OF EVIDENCE: 3:

Indexed as

local recurrenceoverall survivalradiotherapyRenal cell carcinomasystemic therapy

Identifiers

PMID38964886
PMCPMC11535771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.