Evidence map›Paper›PMID 38964308›Full record

ArticleFetal diagnosis and therapy2024

Predictive Value of the sFlt-1/PlGF Ratio and Interleukin-6 for the Presence of Placental Lesions in Spontaneous Preterm Labor with Intact Membranes with Delivery within 7 Days.

Marian Kacerovsky, Helena Hornychova, Magdalena Holeckova, Ladislava Pavlikova, Jitka Rezabkova Chloubova, Bo Jacobsson, Ivana Musilova

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Article in Fetal diagnosis and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Marian KacerovskyBiomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Helena HornychovaFingerland's Department of Pathology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Magdalena HoleckovaInstitute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Ladislava PavlikovaInstitute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Jitka Rezabkova ChloubovaDepartment of Obstetrics and Gynecology, Hospital Most, Krajska zdravotni a.s., Most, Czechia.
Bo JacobssonInstitute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czechia.
Ivana MusilovaBiomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the study was to identify predictive values of the soluble fms-like tyrosine kinase/placental growth factor (sFlt-1/PlGF) ratio and interleukin (IL)-6, assessed with a clinically available method in a large-volume biochemistry laboratory, in maternal blood, amniotic fluid, and umbilical cord blood for the presence of the placental lesions consistent with maternal vascular malperfusion (MVM) and acute histological chorioamnionitis (HCA), respectively.

methodsThis retrospective study included 92 women with preterm labor with intact membranes (PTL) delivered within 7 days of admission with gestational ages between 22+0 and 34+6 weeks. The sFlt-1/PlGF ratio and IL-6 were assessed in stored samples of maternal serum, amniotic fluid, and umbilical cord serum using Elecsys® sFlt-1, PlGF, and IL-6 immunoassays.

resultsWomen with MVM had a higher sFlt-1/PlGF ratio in the maternal serum, compared to those without MVM (19.9 vs. 4.6; p < 0.0001), but not in the amniotic fluid or umbilical cord blood. A cut-off value of 8 for the sFlt-1/PlGF ratio in maternal serum was identified as optimal for predicting MVM in patients with PTL. Women with HCA had higher concentrations of IL-6 in maternal serum, compared to those without HCA (11.1 pg/mL vs. 8.4 pg/mL; p = 0.03), amniotic fluid (9,216 pg/mL vs. 1,423 pg/mL; p < 0.0001), and umbilical cord blood (20.7 pg/mL vs. 10.7 pg/mL, p = 0.002). Amniotic-fluid IL-6 showed the highest predictive value. A cut-off value of IL-6 concentration in the amniotic fluid of 5,000 pg/mL was found to be optimal for predicting HCA in PTL.

conclusionMaternal serum sFlt-1/PlGF and amniotic fluid IL-6 concentrations can be used for liquid biopsy to predict placental lesions in women with PTL who deliver within 7 days.

Indexed as

Interleukin-6Obstetric Labor, PrematurePlacenta Growth FactorPredictive Value of TestsVascular Endothelial Growth Factor Receptor-1AdultAmniotic FluidBiomarkersChorioamnionitisFemaleFetal BloodHumansPlacentaPregnancyRetrospective StudiesBiomarkersFLT1 protein, humanIL6 protein, humanInterleukin-6PGF protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1AmniocentesisAmniotic fluidAngiogenic factorsBiomarkerInflammationInterleukin-6PlGFPreeclampsiaPregnancyPreterm birthPreterm labor with intact membraneRapid point-of-care testReceptorsFlt-1VEGF

Identifiers

PMID38964308
PMCPMC11633894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.