ArticleeLife2024
The breath shape controls intonation of mouse vocalizations.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Disruption of ultrasonic vocalizations with systemic administration of the non-competitive N-methyl-D-aspartate receptor antagonist MK-801 in adult male mice.The international journal of neuropsychopharmacology · 2026Article
- Sensory nerve-derived signaling coordinates oropharyngeal structural organization that supports suckling and vocalization in neonatal mice.Nature communications · 2026Article
- Maternal exposure to titanium dioxide nanoparticles disrupts ultrasonic vocalization development in mouse offspring.Particle and fibre toxicology · 2026Article
- Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node.Current biology : CB · 2025Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
- Courtship and distress ultrasonic vocalizations are altered in a mouse model of Angelman syndrome.Journal of neurodevelopmental disorders · 2025Article
- A harbor seal (Phoca vitulina) shows extensive respiratory control in sound production.BMC ecology and evolution · 2025Article
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- The multifunctionality of the brainstem breathing control circuit.Current opinion in neurobiology · 2025Review
- Molecular changes, histopathology, and ultrasonic vocalization acoustic profiles of systemically dehydrated rats.PloS one · 2025Article
- Activation of the periaqueductal gray controls respiratory output through a distributed brain network.Frontiers in physiology · 2025Article
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4 authors.
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Abstract
Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct sounds with different denotations, like in tonal languages and, perhaps, the 10 sounds in the murine lexicon. A basic tone is created by exhalation through a constricted laryngeal voice box, and it is thought that more complex utterances are produced solely by dynamic changes in laryngeal tension. But perhaps, the shifting pitch also results from altering the swiftness of exhalation. Consistent with the latter model, we describe that intonation in most vocalization types follows deviations in exhalation that appear to be generated by the re-activation of the cardinal breathing muscle for inspiration. We also show that the brainstem vocalization central pattern generator, the iRO, can create this breath pattern. Consequently, ectopic activation of the iRO not only induces phonation, but also the pitch patterns that compose most of the vocalizations in the murine lexicon. These results reveal a novel brainstem mechanism for intonation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.