ArticleInfection2024
Gentamicin combination treatment is associated with lower mortality in patients with invasive listeriosis: a retrospective analysis.
Article in Infection, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Aggressive brainstem listeria abscess in an immunocompetent individual: A case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Clinical Characteristics and Outcomes of InvasiveOpen forum infectious diseases · 2026Article
- Comprehensive Phenotypic and Genomic Study for Understanding the Variability in Susceptibility of Listeria monocytogenes to AMPs and Bacteriocins.Probiotics and antimicrobial proteins · 2026Article
- Risk factors and outcomes of emerging Listeria monocytogenes infection in Pakistan: Insights from a tertiary care hospital.PloS one · 2026Article
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- Article
- Challenges in interpreting the role of gentamicin in treatment of invasive listeriosis: immortal time bias and confounding.Infection · 2025Article
- Severe listeriosis in intensive care units: insights from a retrospective multicentric study.Critical care (London, England) · 2025Observational
- Recent Advances in Host Immune Mechanisms AgainstJournal of inflammation research · 2025Review
- Virulence Gene Profiling and Molecular Typing of Clinical Isolates ofInfection and drug resistance · 2025Article
- Clinical, molecular, and resistance features ofPeerJ · 2025Article
- Article
- Case Series ofMicroorganisms · 2024Article
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10 authors.
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Abstract
purposeListeria monocytogenes causes severe bacterial infections with the highest mortality rate among foodborne pathogens in Europe. Combination treatment with ampicillin and gentamicin is recommended for invasive manifestations. However, evidence to support this treatment approach remains limited due to a lack of randomised controlled trials. To explore this critical issue further, we conducted this retrospective, single-center study.
methodsWe identified all patients hospitalized with invasive listeriosis at the University Medical Center Hamburg-Eppendorf between 2009 and 2020 and analyzed the effect of gentamicin combination treatment versus monotherapy on 90-day mortality.
resultsIn total, 36 patients with invasive listeriosis were included, of which 21 patients received gentamicin combination treatment and 15 received monotherapy. The mean age-adjusted Charlson Comorbidity Index (aaCCI) value was lower in the gentamicin combination treatment group (5.4 vs. 7.4). Neurolisteriosis was more common in the gentamicin group (81% vs. 20%). The 90-day mortality was with significantly lower in the gentamicin combination treatment group (10%) compared to the monotherapy group (60%). Multivariable cox regression analysis, adjusted for a propensity score computed based on neurolisteriosis, aaCCI and sex, revealed a significantly reduced hazard ratio of 0.07 (95% CI: 0.01-0.53, p = 0.01) for 90-day mortality for the gentamicin combination treatment.
conclusionThis retrospective study highlights the benefit of gentamicin combination treatment in reducing the 90-day mortality rate among patients with invasive listeriosis. The high prevalence of monotherapy in this study cohort raises concerns about the adequacy of antibiotic therapy in clinical practice.
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