Evidence map›Paper›PMID 38963562›Full record

ArticleBasic research in cardiology2024

Bone marrow cells contribute to seven different endothelial cell populations in the heart.

Parisa Shabani, Vahagn Ohanyan, Ammar Alghadeer, Daniel Gavazzi, Feng Dong, Liya Yin, Christopher Kolz, Lindsay Shockling, Molly Enrick, Ping Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. MertkImmunity, inflammation and disease · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Parisa ShabaniDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Vahagn OhanyanDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Ammar AlghadeerDepartment of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia.
Daniel GavazziHiram College Physics and Computer Science Department, Hiram, OH, USA.
Feng DongDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Liya YinDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Christopher KolzDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Lindsay ShocklingDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Molly EnrickDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Ping ZhangDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Xin ShiDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
William ChilianDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA. wchilian@neomed.edu.ORCID 0000-0003-4522-7914

Funding

What mechanisms underlie coronary collateral growth?R01HL135110 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI CHILIAN, WILLIAM M, YIN, LIYA · 2017 to 2020
$1.7M
Mechanisms of Impaired Coronary Collateral GrowthR01HL137008 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI YIN, LIYA · 2018 to 2021
$1.6M
Foundation for the National Institutes of Health GM1332449Foundation for the National Institutes of Health HL132240Foundation for the National Institutes of Health HL135110Foundation for the National Institutes of Health HL137008Foundation for the National Institutes of Health HL157495Foundation for the National Institutes of Health HL161512NHLBI NIH HHS R01 HL135110NHLBI NIH HHS R01 HL137008
6 · The paper itself

Abstract

Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic strategies for myocardial ischemia. This study investigates the contribution of bone marrow-derived cells to endothelial cell populations in the heart, and their role in cardiac function and coronary circulation following repetitive ischemia (RI). Chimeric rats were created by transplanting BM cells from GFP female rats into irradiated male recipients. After engraftment chimeras were subjected to RI for 17 days. Vascular growth was assessed from recovery of cardiac function and increases in myocardial blood flow during LAD occlusion. After sorting GFP

Indexed as

Bone Marrow TransplantationDisease Models, AnimalEndothelial CellsRats, TransgenicAnimalsBone Marrow CellsCoronary CirculationFemaleMaleMyocardial IschemiaMyocardiumNeovascularization, PhysiologicRatsRats, Sprague-DawleyTranscriptomeBone marrow stem cellsCoronary circulationCoronary collateralsMyocardial ischemiaSingle-cell RNA sequencing

Identifiers

PMID38963562
PMCPMC11319501

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.