Evidence map›Paper›PMID 38963536›Full record

ArticleInflammopharmacology2024

Chemical composition and studying the possible neuroprotective effect of iridoids-rich fraction from Pentas lanceolata leaves using rotenone model of Parkinson's disease in mice.

Ahmed H Afifi, Heba-Tollah M Sweelam, Marwa E El-Shamarka, Hisham A Orban, Wessam H Elesawy, Maki Nagata, Kuniyoshi Shimizu, Howaida I Abd-Alla

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed H AfifiPharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, 12622, Giza, Egypt.
Heba-Tollah M SweelamChemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, 12622, Giza, Egypt.
Marwa E El-ShamarkaNarcotics, Ergogenics and Poisons Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, 12622, Giza, Egypt.
Hisham A OrbanBiochemistry Department, Department of Medical Biochemistry, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, 12622, Giza, Egypt.
Wessam H ElesawyPharmacology and Toxicology Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6 October, Egypt.
Maki NagataDepartment of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan.
Kuniyoshi ShimizuPharmacology and Toxicology Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6 October, Egypt.
Howaida I Abd-AllaChemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, 12622, Giza, Egypt. howaida_nrc@yahoo.com.ORCID http://orcid.org/0000-0001-9638-8481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinsonism is an age-related neurodegenerative illness that affects motor coordination leading to loss of dopaminergic neurons. Many medications are used for the treatment of Parkinson's disease but are only symptomatic and have a limited effect on the progression of this ailment. Therefore, bioactive compounds which derived from plants have been examined for their ability to improve the neuronal damage and cell death happened in parkinsonian patients. In this study the iridoids-rich fraction isolated from Pentas lanceolata (PIRF) leaves was investigated for its phytoconstituents. Seven iridoids (1-7) and one flavonol diglycoside (8) were isolated, and their chemical structures were achieved by

Indexed as

Disease Models, AnimalIridoidsNeuroprotective AgentsPlant ExtractsPlant LeavesRotenoneAnimalsMaleMiceParkinson DiseaseParkinsonian DisordersIridoidsNeuroprotective AgentsPlant ExtractsRotenoneBehavioral tests RotenoneMotor functionsParkinson's diseasePentas lanceolataPlant iridoids

Identifiers

PMID38963536
PMCPMC11550285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.