ReviewAnnals of intensive care2024
The use of Guyton's approach to the control of cardiac output for clinical fluid management.
Review in Annals of intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07722325 (Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Venous Return Pressure Gradient Predicts Acute Kidney Injury Onset and Progression
Who cites it
10 citing papers in PubMed.
- Central Venous Pressure Referencing in the Lateral Position: Comparison With Direct Right Atrial Pressure in Mechanically Ventilated ICU Patients.Acta anaesthesiologica Scandinavica · 2026Observational
- Influence of adrenergic drugs and volume loading on mean systemic filling pressure in non-septic and septic sheep.Frontiers in medicine · 2026Article
- Dynamics of ventriculo-arterial coupling and peripheral tissue perfusion during early resuscitation of septic shock.Annals of intensive care · 2026Article
- Pulmonary pulsatility quantified by electrical impedance tomography in severe acute respiratory distress syndrome patients undergoing extracorporeal membrane oxygenation support.Annals of intensive care · 2026Article
- Transcranial ultrasound in the critically ill patient: a narrative review.Intensive care medicine experimental · 2025Review
- Head-to-head comparison of V-A ECMO, Impella and ECPELLA in normal ovine hearts.Scientific reports · 2025Article
- Physiological complexities of intraabdominal hypertension: taming the elephant.Annals of intensive care · 2025Article
- Effect of manual decongestive therapy on cardiac preload in critically ill patients: a randomized controlled trial.Annals of intensive care · 2025Article
- Guyton's hemodynamic mosaic: crafting fluid management with precision.Annals of intensive care · 2025Article
- Right atrial pressure and Guyton's approach to fluid management.Annals of intensive care · 2024Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Infusion of fluids is one of the most common medical acts when resuscitating critically ill patients. However, fluids most often are given without consideration of how fluid infusion can actually improve tissue perfusion. Arthur Guyton's analysis of the circulation was based on how cardiac output is determined by the interaction of the factors determining the return of blood to the heart, i.e. venous return, and the factors that determine the output from the heart, i.e. pump function. His theoretical approach can be used to understand what fluids can and cannot do. In his graphical analysis, right atrial pressure (RAP) is at the center of this interaction and thus indicates the status of these two functions. Accordingly, trends in RAP and cardiac output (or a surrogate of cardiac output) can provide important guides for the cause of a hemodynamic deterioration, the potential role of fluids, the limits of their use, and when the fluid is given, the response to therapeutic interventions. Use of the trends in these values provide a physiologically grounded approach to clinical fluid management.
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