Evidence map›Paper›PMID 38963523›Full record

ArticleJournal of nephrology2025

Bone mineral density assessment in patients with cystinuria.

Viola D'Ambrosio, Giovanna Capolongo, Chiara Caletti, Maria Teresa Vietri, Martina Ambrogio, Gianmarco Lombardi, Alessandra F Perna, Giuseppe Orefice, Elisa Gremese, Valentina Varriano and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Viola D'AmbrosioUniversità Cattolica del Sacro Cuore, Rome, Italy.
Giovanna CapolongoDepartment of Medical Translational Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Chiara CalettiSection of Nephrology, Department of Medicine, Università Degli Studi Di Verona, Verona, Italy.
Maria Teresa VietriDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio, 80138, Naples, Italy.
Martina AmbrogioUniversità Cattolica del Sacro Cuore, Rome, Italy.
Gianmarco LombardiSection of Nephrology, Department of Medicine, Università Degli Studi Di Verona, Verona, Italy.
Alessandra F PernaDepartment of Medical Translational Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Giuseppe OreficeDepartment of Medical Translational Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Elisa GremeseUnit of Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Valentina VarrianoUnit of Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Davide GattiSection of Rheumatology, Department of Medicine, Università Degli Studi Di Verona, Verona, Italy.
Angelo FassioSection of Rheumatology, Department of Medicine, Università Degli Studi Di Verona, Verona, Italy.
Giovambattista CapassoDepartment of Medical Translational Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Giovanni GambaroSection of Nephrology, Department of Medicine, Università Degli Studi Di Verona, Verona, Italy.
Pietro Manuel FerraroSection of Nephrology, Department of Medicine, Università Degli Studi Di Verona, Verona, Italy. pietromanuel.ferraro@univr.it.ORCID 0000-0002-1379-022X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCystinuria is a rare genetic disease characterized by impaired tubular transport of cystine. Clinical features of cystinuria mainly include nephrolithiasis and its complications, although cystinuric patients may present with other comorbidities. There are currently no data on bone features of patients with cystinuria. Our aim is to characterize bone mineral density (BMD) in cystinuria.

methodsOur study included adult cystinuric patients with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m

resultsTwenty-seven patients were included in the study. Mean (SD) age was 37 (15) years, 41% were women. Mean estimated glomerular filtration rate was 99 mL/min/1.73 m

conclusionsOur study suggests that cystinuric patients have lower bone mineral density compared with individuals of the same sex and age, even when their kidney function is normal.

Indexed as

Bone DensityCystinuriaAbsorptiometry, PhotonAdultBiomarkersFemaleFibroblast Growth Factor-23Glomerular Filtration RateHumansItalyMaleMiddle AgedBiomarkersFGF23 protein, humanFibroblast Growth Factor-23Bone mineral densityCystinuriaNephrolithiasisOsteopenia

Identifiers

PMID38963523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.