Evidence map›Paper›PMID 38963513›Full record

ReviewCurrent pain and headache reports2024

A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain.

Rodney A Gabriel, Eri C Seng, Brian P Curran, Paul Winston, Andrea M Trescot, Igor Filipovski

Registry-linked trialAbstract readReview
In one paragraph

Review in Current pain and headache reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06646731 (Ultrasound-guided Percutaneous Cryoneurolysis for Management of Chronic Painful Diabetic Neuropathy), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06646731 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Ultrasound-guided Percutaneous Cryoneurolysis for Management of Chronic Painful Diabetic Neuropathy: A Randomized Sham-controlled Pilot Study

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2026Enrolled30ConditionsPainful Diabetic Peripheral Neuropathy (PDPN)Armscryoneurolysis, sham cryoneurolysis
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Cryoneurolysis of Sacral Lateral Branches for Chronic Sacroiliac Joint Pain: A Multicenter Retrospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rodney A GabrielUniversity of California, San Diego, La Jolla, CA, California, USA. ragabriel@health.ucsd.edu.
Eri C SengUniversity of California, San Diego, La Jolla, CA, California, USA.
Brian P CurranUniversity of California, San Diego, La Jolla, CA, California, USA.
Paul WinstonUniversity of British Columbia, Vancouver, Canada.
Andrea M TrescotFlorida Pain Relief Group, Tampa, FL, USA.
Igor FilipovskiCopenhagen Cryo Center, Copenhagen, DNK, Denmark.

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

purpose of reviewCryoneurolysis refers to the process of reversibly ablating peripheral nerves with extremely cold temperatures to provide analgesia for weeks to months. With ultrasound-guidance or landmark-based techniques, it is an effective modality for managing both acute and chronic pain. In this review, we summarize the reported literature behind its potential applications and efficacy. RECENT

findingsHere, we summarize several studies (from case reports to clinical trials) describing the use of ultrasound-guided and landmark-based cryoneurolysis for acute and chronic pain. Acute pain indications included pain related to knee arthroplasty, limb amputations, mastectomies, shoulder surgery, rib fractures, and burn. Chronic pain indications included chronic knee pain (due to osteoarthritis), shoulder pain, painful neuropathies, postmastectomy pain syndrome, phantom limb pain, facial pain/headaches, foot/ankle pain, inguinal pain, and sacroiliac joint pain. For both acute and chronic pain indications, more high quality randomized controlled clinical trials are needed to definitively assess the efficacy of cryoneurolysis versus other standard therapies for a multitude of pain conditions.

Indexed as

Acute PainChronic PainPain ManagementUltrasonography, InterventionalCryosurgeryHumansAcute painChronic painCryoanalgesiaCryoneurolysisUltrasound

Identifiers

PMID38963513
PMCPMC11461560

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.