Structures and Electron Transport Paths in the Four Families of Flavin-Based Electron Bifurcation Enzymes.

Xiang Feng, Gerrit J Schut, Michael W W Adams, Huilin Li

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In one paragraph

Review in Sub-cellular biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

An electron-bifurcating "plug" to a protein nanowire in tungsten-dependent aldehyde detoxification.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Xiang FengDivision of Chemistry and Chemical Engineering, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.ORCID https://orcid.org/0000-0002-4441-3152

Gerrit J SchutDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0002-3694-1799

Michael W W AdamsDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.ORCID https://orcid.org/0000-0003-0881-8870

Huilin LiDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA. Huilin.Li@vai.org.ORCID https://orcid.org/0000-0001-8085-8928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidoreductases facilitating electron transfer between molecules are pivotal in metabolic pathways. Flavin-based electron bifurcation (FBEB), a recently discovered energy coupling mechanism in oxidoreductases, enables the reversible division of electron pairs into two acceptors, bridging exergonic and otherwise unfeasible endergonic reactions. This chapter explores the four distinct FBEB complex families and highlights a decade of structural insights into FBEB complexes. In this chapter, we discuss the architecture, electron transfer routes, and conformational changes across all FBEB families, revealing the structural foundation that facilitate these remarkable functions.

Indexed as

FlavinsElectron TransportModels, MolecularOxidation-ReductionOxidoreductasesProtein ConformationFlavinsOxidoreductasesCatalytic mechanismcryoEMElectron bifurcationElectron transferFlavinIron-sulfur clusterStructural biology

Identifiers

PMID38963493

DOI10.1016/j.bbabio.2021.148401

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