Evidence map›Paper›PMID 38963447›Full record

ArticleAnnals of hematology2024

Comorbidities and survival of multiple myeloma patients diagnosed in Finland between 2000 and 2021.

Kai Kysenius, Anna Anttalainen, Iiro Toppila, Tatu Miettinen, Mariann Lassenius, Juha Lievonen, Anu Partanen, Raija Silvennoinen, Mervi Putkonen

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Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kai KyseniusMedaffcon Oy, Espoo, Finland. kai.kysenius@medaffcon.fi.
Anna AnttalainenMedaffcon Oy, Espoo, Finland.
Iiro ToppilaMedaffcon Oy, Espoo, Finland.
Tatu MiettinenMedaffcon Oy, Espoo, Finland.
Mariann LasseniusMedaffcon Oy, Espoo, Finland.
Juha LievonenDepartment of Hematology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anu PartanenDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Raija SilvennoinenDepartment of Hematology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mervi PutkonenDepartment of Hematology, Turku University Hospital, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in treatment have improved the survival of multiple myeloma (MM) patients, but the disease remains incurable. Here, in this nationwide retrospective real-world evidence (RWE) study, we report the patient characteristics, incidence, overall survival outcomes, comorbidities, and healthcare resource utilization (HCRU) of all adult MM patients diagnosed between 2000 and 2021 in Finland. A total of 7070 MM patients and their 21,210 age-, sex- and region-matched controls were included in the analysis. The average MM incidence doubled from 4.11 to 8.33 per 100,000 people during the follow-up. The average age-standardized incidence also showed a significant increase over time (2.51 in 2000 to 3.53 in 2021). An increase in incidence was particularly seen in older population, indicative of improved diagnosis praxis. The median overall survival (mOS) of the MM patients and their matched controls was 3.6 and 15.6 years, respectively. The mOS of all MM patients increased significantly from 2.8 years (2000-2004) to 4.4 years (2017-2021) during the follow-up period. Distinctively, in patients who received autologous stem cell transplantation (ASCT), the mOS was 9.2 years, while in patients who did not receive ASCT, the mOS was only 2.7 years. MM patients showed more comorbidities at index and increased HCRU than their matched controls. The longer median survival and decreased risk of death indicate improved treatment outcomes in MM patients in Finland.

Indexed as

ComorbidityMultiple MyelomaAdultAgedAged, 80 and overFemaleFinlandFollow-Up StudiesHematopoietic Stem Cell TransplantationHumansIncidenceMaleMiddle AgedRetrospective StudiesSurvival RateTransplantation, AutologousAutologous stem cell transplant (ASCT)ComorbiditiesHematologyMultiple myelomaOncologyReal-world evidence (RWE)

Identifiers

PMID38963447
PMCPMC11380637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.