ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2024
A scoping review of the evidence on pharmacological and nonpharmacological interventions for idiopathic hypersomnia.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
STUDY
objectivesIdiopathic hypersomnia (IH) is characterized by excessive sleepiness during the day, prolonged sleep at night, and difficulty waking up. The true prevalence of IH is uncertain. The
methodsTo conduct this review, a comprehensive search was conducted across scientific databases, without any restrictions on the date or study type. Eligible studies examined the effectiveness of pharmacologic and nonpharmacologic treatments for IH and reported the outcomes of these interventions. Data from the studies were screened, analyzed, and synthesized to provide an overview of the available literature landscape.
resultsFifty-one studies were included in this review, which used various methods and interventions. Pharmacological treatments, particularly modafinil, have been frequently studied and have yielded positive results. There is also emerging evidence for alternative medications such as low-sodium oxybate and pitolisant. Nonpharmacological approaches, such as cognitive behavioral therapy for hypersomnia and transcranial direct current stimulation have also shown promise in managing IH.
conclusionsThis review highlights the complexity of managing IH symptoms and emphasizes the need for personalized multidisciplinary approaches. Pharmacological interventions are important in managing IH and can be complemented by nonmedication strategies. Larger-scale studies are necessary to advance our understanding of IH and to improve treatment outcomes. CITATION: Saini V, Saini S. A scoping review of the evidence on pharmacological and nonpharmacological interventions for idiopathic hypersomnia.
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