ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sequential scans ofJapanese journal of radiology · 2026Article
- Enhancing the Diagnostic Accuracy of Amyloid PET: The Impact of MR-Guided PET Reconstruction.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Brain protein burden is related to intravoxel incoherent motion: PET-MR imaging study.Frontiers in neuroscience · 2026Article
- Deep Learning-Based Prediction of PET Amyloid Status Using MRI.AJNR. American journal of neuroradiology · 2025Article
- Exploring Centiloid Robustness: Impact of Sample Size and Image Resolution on Centiloid Conversion Accuracy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Added Value of Amyloid PET Quantification with the Centiloid Scale in Clinical Practice.AJNR. American journal of neuroradiology · 2025Article
- Comparison of amyloid PET acquired through standardized and unstandardized protocols.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cut-points and gray zones: The challenges of integrating Alzheimer's disease plasma biomarkers into clinical practice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Identification of patients receiving amyloid-targeting therapies in observational studies using amyloid PET trajectories: Insights from LEADS.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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19 authors.
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Abstract
introductionAmyloid positron emission tomography (PET) acquisition timing impacts quantification.
methodsIn florbetaben (FBB) PET scans of 245 adults with and without cognitive impairment, we investigated the impact of post-injection acquisition time on Centiloids (CLs) across five reference regions. CL equations for FBB were derived using standard methods, using FBB data collected between 90 and 110 min with paired Pittsburgh compound B data. Linear mixed models and t-tests evaluated the impact of acquisition time on CL increases.
resultsCL values increased significantly over the scan using the whole cerebellum, cerebellar gray matter, and brainstem as reference regions, particularly in amyloid-positive individuals. In contrast, CLs based on white matter-containing reference regions decreased across the scan. DISCUSSION: The quantification of CLs in FBB PET imaging is influenced by both the overall scan acquisition time and the choice of reference region. Standardized acquisition protocols or the application of acquisition time-specific CL equations should be implemented in clinical protocols. HIGHLIGHTS: Acquisition timing affects florbetaben positron emission tomography (PET) scan quantification, especially in amyloid-positive participants. The impact of acquisition timing on quantification varies across common reference regions. Consistent acquisitions and/or appropriate post-injection adjustments are needed to ensure comparability of PET data.
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