Evidence map›Paper›PMID 38962676›Full record

ArticleFrontiers in endocrinology2024

Characterization of the effects of cannabinoid receptor deletion on energy metabolism in female C57BL mice.

Morgan Sotzen, Ahmed Ahmed, L Karl Olson, Omayma Alshaarawy

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Morgan SotzenDepartment of Family Medicine, Michigan State University, East Lansing, MI, United States.
Ahmed AhmedDepartment of Family Medicine, Michigan State University, East Lansing, MI, United States.
L Karl OlsonDepartment of Physiology, Michigan State University, East Lansing, MI, United States.
Omayma AlshaarawyDepartment of Family Medicine, Michigan State University, East Lansing, MI, United States.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Background: Despite the evidence that energy balance is regulated differently in females and that the endocannabinoid system is sexually dimorphic, previous studies on the endocannabinoid system and energy balance predominantly used male models. Here, we characterize the effects of cannabinoid receptor deletion on body weight gain and glucose metabolism in female C57BL mice. Methods: Female mice lacking the cannabinoid-1 receptor (CB1R Results: Female WT mice fed with HFD gained significantly more weight than WT mice fed with LFD (p < 0.001). Similar pattern was observed for CB2 Conclusion: The effects of cannabinoid receptor deletion on glucose metabolism in female mice were similar to previously published findings on male mice, yet the effects on body weight gain and thermogenesis were attenuated in CB1R

Indexed as

Diet, High-FatEnergy MetabolismMice, Inbred C57BLMice, KnockoutReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Weight GainAnimalsBody WeightFemaleMiceCNR1 protein, mouseReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2body weightcannabinoidsfemaleglucose metabolismthermogenesis

Identifiers

PMID38962676
PMCPMC11221337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.