Evidence map›Paper›PMID 38962579›Full record

ArticleAnnual review of statistics and its application2024

Making Sense of Censored Covariates: Statistical Methods for Studies of Huntington's Disease.

Sarah C Lotspeich, Marissa C Ashner, Jesus E Vazquez, Brian D Richardson, Kyle F Grosser, Benjamin E Bodek, Tanya P Garcia

Abstract read
In one paragraph

Article in Annual review of statistics and its application, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. SPARCC: Semi-Parametric Robust Estimation in a Right-Censored Covariate Model.Journal of the American Statistical Association · 2026
    Article
  4. Robust evaluation of longitudinal surrogate markers with censored data.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah C LotspeichDepartment of Statistical Sciences, Wake Forest University, Winston-Salem, North Carolina, USA.
Marissa C AshnerDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jesus E VazquezDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brian D RichardsonDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kyle F GrosserDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Benjamin E BodekDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Tanya P GarciaDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Landis Award for Outstanding Mentorship: Administrative Supplement to NS131225R01NS131225 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Tanya Pamela Garcia · 2023 to 2026
$2.2M
Innovative Statistical Models for Development of First Huntington's Disease Progression Risk Assessment ToolK01NS099343 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GARCIA, TANYA PAMELA · 2017 to 2019
$739k
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS T32 ES007018NINDS NIH HHS K01 NS099343NINDS NIH HHS R01 NS131225
6 · The paper itself

Abstract

The landscape of survival analysis is constantly being revolutionized to answer biomedical challenges, most recently the statistical challenge of censored covariates rather than outcomes. There are many promising strategies to tackle censored covariates, including weighting, imputation, maximum likelihood, and Bayesian methods. Still, this is a relatively fresh area of research, different from the areas of censored outcomes (i.e., survival analysis) or missing covariates. In this review, we discuss the unique statistical challenges encountered when handling censored covariates and provide an in-depth review of existing methods designed to address those challenges. We emphasize each method's relative strengths and weaknesses, providing recommendations to help investigators pinpoint the best approach to handling censored covariates in their data.

Indexed as

censored covariateHuntington’s diseaseimputationinverse probability weightinglikelihoodsurvival analysisthresholding

Identifiers

PMID38962579
PMCPMC11220439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.