ArticleCancer diagnosis & prognosis
Geriatric Nutritional Risk Index as Prognostic Marker for Elderly Patients With Small Cell Lung Cancer.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Prognostic relevance of geriatric nutritional risk index and the prognostic nutritional index in geriatric extensive stage small cell lung cancer.Scientific reports · 2025Article
- Prognostic Power of the Naples Score in Non-Small Cell Lung Cancer: Can Inflammation and Nutrition Predict Survival?Journal of clinical medicine · 2025Article
- Article
- Nutritional and inflammatory markers for predicting delirium after radical hysterectomy for cervical cancer: development of a nomogram.Frontiers in nutrition · 2025Article
- The Effect of Malnutrition on Treatment Efficacy and Toxicity in Geriatric Patients Treated With Immune Checkpoint Inhibitors.Cancer diagnosis & prognosisArticle
- "Gerontosurgery": Evaluation of Multidimensional Assessment Scales for Elderly Patients Undergoing Major Abdominal Surgery. What Is the Best Prediction Model?In vivo (Athens, Greece)Observational
- External Validation of an Extended Prognostic Assessment Model in Patients With Brain Metastases from Small-cell Lung Cancer.Cancer diagnosis & prognosisArticle
- Usefulness of White Blood Cell Differential-based Indices in Patients With Extensive-stage Small Cell Lung Cancer.Cancer diagnosis & prognosisArticle
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Authors and funding
7 authors.
Funding
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Abstract
Background/Aim: The Geriatric Nutritional Risk Index (GNRI) indicates nutritional status based on serum albumin concentration and ideal body weight. Pretreatment GNRI has been suggested as a prognostic factor for various malignancies. However, little is known about the clinical value of GNRI for small-cell lung cancer (SCLC), especially in elderly patients. Patients and Methods: We retrospectively analyzed 53 elderly (≥71) patients with extensive-disease (ED) SCLC treated with first-line platinum-doublet chemotherapy in relation to the pretreatment GNRI level in a real-world setting. Results: Thirty-six patients with a low GNRI (<92) had statistically poorer progression-free survival (PFS) and overall survival (OS) than 17 patients with a high GNRI (≥92) (median PFS=80 days vs. 133 days, respectively; p=0.002; median OS=123 days vs. 274 days, respectively; p=0.004). In a multivariate analysis, a low GNRI was also an independent poor prognostic factor for PFS [hazard ratio (HR)=0.396; 95% confidence interval (CI)=0.199-0.789; p=0.008] and OS (HR=0.295; 95%CI=0.143-0.608; p<0.001). Conclusion: The GNRI might be a predictive and prognostic marker in elderly patients with ED-SCLC treated with platinum-doublet chemotherapy.
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