Evidence map›Paper›PMID 38962491›Full record

ArticleRegenerative therapy2024

The therapeutic effect of sufficient oxygen-rich PRP injection in facial rejuvenation by multiple objective evaluations in 26 cases.

Jianyun Lu, Tong Zhang, Lu Zhou, Xiaoliang Tong, Rong Gui, Ling Jiang, Zhen Tang, Yunfeng Fu, Guosheng Zhao, Jinrong Zeng and 1 more

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Article in Regenerative therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jianyun LuDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Tong ZhangXiangya Medical College, Central South University, Changsha, China.
Lu ZhouDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiaoliang TongDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Rong GuiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Ling JiangDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhen TangDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yunfeng FuDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Guosheng ZhaoDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Jinrong ZengDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.
Lihua GaoDepartments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ozone can enhance the expression of some growth factors (GFs) in platelet rich plasma (PRP), recent study showed oxygen-rich PRP (ozonized PRP) have better therapeutic effects on bone and joint diseases. PRP injection has been widely used in the treatment of facial rejuvenation, but the efficacy of sufficient oxygen-rich PRP in facial rejuvenation has not been studied. Objective: Firstly, we examined whether ozone treatment can increase the concentration of GFs of PRP in vitro. And then a variety of subjective and objective detection methods were used to evaluate the effect of sufficient(10-12 mL each time for the injection of face and neck) oxygen-rich (ozonized PRP) PRP injection in facial rejuvenation by follow-up for 6 months. At last, we investigated the satisfaction, side effects and pain score of the treatment through a questionnaire survey. Methods: The concentration of main GFs in PRP treated with different dose of ozone in vitro was measured by ELISA. Clinical picture, the collagen thickness of dermis by reflectance confocal microscope(RCM), skin conditions (including spots, ultraviolet (UV) spots, brown spots, red area, pores, wrinkles, texture and porphyrin) by VISIA were collected before treatment and each month follow-up visit after treatment until 6-month follow-up period was finished. Patients' satisfaction, side effects and pain score were collected at the end of follow-up period. Results: PRP treated by high-dose ozone (57 μg/mL, ozone/PRP volume ratio:1/1) in vitro showed a significant increase in endothelial growth factor (EGF) and transforming growth factor-β (TGF-β) compared to baseline( Conclusions: Ozone treatment can increase the concentration of GFs such as EGF and TGF-β in PRP in vitro. Sufficient oxygen-rich PRP injection may be an effective and promising method to treat facial rejuvenation.

Indexed as

CollagenFacial rejuvenationOzonePlatelet rich plasmaRCM

Identifiers

PMID38962491
PMCPMC11219273

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