Evidence map›Paper›PMID 38962455›Full record

ArticleFrontiers in tropical diseases2021

Marla I Hertz, Irene Hamlin, Amy Rush, Philip J Budge

Abstract read
In one paragraph

Article in Frontiers in tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marla I HertzDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Irene HamlinDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Amy RushDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Philip J BudgeDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
IMPROVED ANTIGEN DETECTION TESTS FOR FILARIAL INFECTIONSK08AI121422 · NIAID · WASHINGTON UNIVERSITY · PI BUDGE, PHILIP · 2016 to 2020
$856k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS K08 AI121422NIGMS NIH HHS P41 GM103422
6 · The paper itself

Abstract

Background: Rapid and accurate prevalence mapping of lymphatic filariasis (LF) is necessary to eliminate this disfiguring and disabling neglected tropical disease. Unfortunately, rapid tests such as the filariasis test strip (FTS) for Methods: To gain a better understanding of the proteins recognized by the FTS diagnostic antibody, we used proteomics and lectin array technology to characterize filarial glycoproteins that are bound by the AD12.1 antibody using Results: Distinct but overlapping sets of AD12 glycoproteins were identified from somatic and excretory/secretory worm products. One of the identified proteins, Bm18019 was confirmed as a secreted AD12-reactive glycoprotein by in-gel proteomics and immunoassays. Based on lectin binding patterns, Conclusions:

Indexed as

Brugia malayiglycoproteinloiasislymphatic filariasisrapid diagnostic assays

Identifiers

PMID38962455
PMCPMC11220778

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.