Evidence map›Paper›PMID 38962306›Full record

ArticleFrontiers in pharmacology2024

Assessing genotoxic effects of chemotherapy agents by a robust

Minmin Qu, Jia Chen, Bin Xu, Qinyun Shi, Shujing Zhao, Zhaoxia Wang, Zhi Li, Bo Ma, Hua Xu, Qinong Ye and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Minmin QuDepartment of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
Jia ChenBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Bin XuBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Qinyun ShiBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Shujing ZhaoBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Zhaoxia WangBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Zhi LiBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Bo MaBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Hua XuBeijing Institute of Pharmacology and Toxicology, Beijing, China.
Qinong YeDepartment of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, China.
Jianwei XieBeijing Institute of Pharmacology and Toxicology, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy has already proven widely effective in treating cancer. Chemotherapeutic agents usually include DNA damaging agents and non-DNA damaging agents. Assessing genotoxic effect is significant during chemotherapy drug development, since the ability to attack DNA is the major concern for DNA damaging agents which relates to the therapeutic effect, meanwhile genotoxicity should also be evaluated for chemotherapy agents' safety especially for non-DNA damaging agents. However, currently applicability of

Indexed as

chemotherapy agentsDNA damage repairgenotoxicityHepG2 cellsγ-H2AX

Identifiers

PMID38962306
PMCPMC11219945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.