Evidence map›Paper›PMID 38962041›Full record

ArticleInternational cancer conference journal2024

An autopsy case of lung adenocarcinoma with immune checkpoint inhibitor-induced pneumonia and fulminant myocarditis following pembrolizumab administration: a case report.

Takahiko Hashimoto, Kosuke Takahashi, Kosuke Ito, Kahori Iwade, Atsushi Torii, Minoru Sugihara, Haruka Kondo, Toru Hara

Abstract read
In one paragraph

Article in International cancer conference journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takahiko HashimotoDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showaku, Nagoya, Aichi 466-8560 Japan.
Kosuke TakahashiDepartment of Respiratory Medicine, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-Cho, Anjo, Aichi 446-8602 Japan.
Kosuke ItoDepartment of Respiratory Medicine, Toyota Kosei Hospital, Aichi, Japan.
Kahori IwadeDepartment of Respiratory Medicine, Toyota Memorial Hospital, Aichi, Japan.
Atsushi ToriiDepartment of Respiratory Medicine, Kariya Toyota General Hospital, Aichi, Japan.
Minoru SugiharaDepartment of Thoracic Surgery, Komaki City Hospital, Aichi, Japan.
Haruka KondoDepartment of Respiratory Medicine, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-Cho, Anjo, Aichi 446-8602 Japan.
Toru HaraDepartment of Respiratory Medicine, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-Cho, Anjo, Aichi 446-8602 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) are the current standard of care for non-small-cell lung cancer (NSCLC). Myocarditis is a rare but serious immune-related adverse event (irAE) associated with ICI therapy. We present a patient who received a single dose of pembrolizumab for NSCLC and developed ICI-associated pneumonia. Although pneumonia improved with corticosteroid therapy, the patient subsequently developed ICI-associated fulminant myocarditis. Despite high-dose corticosteroid therapy, the patient died on day 30 after pembrolizumab initiation. Even if an observed irAE was effectively treated, clinicians should remain vigilant for other irAEs, especially those that are difficult to control with low-dose corticosteroids.

Indexed as

Immune checkpoint inhibitorsImmune-related adverse eventsInterstitial pneumoniaMyocarditisNon-small-cell carcinoma

Identifiers

PMID38962041
PMCPMC11217241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.